黄曲霉毒素导致的肝脏生化变化。
Biochemical changes in liver due to aflatoxin.
作者信息
Shankaran P, Shankaran R, Raj H G, Venkitasubramanian T A
出版信息
Br J Exp Pathol. 1970 Oct;51(5):487-91.
The effect of a single dose of aflatoxin on the content of glycogen, lipid and protein of mouse liver was studied 2 hr after injection of the toxin but no significant change was observed. Enzymes in liver of mice were assayed 2 hr and 8 hr after aflatoxin treatment. In general, the enzymes of particulate fraction and isocitrate dehydrogenase in the supernatant showed a significant increase; the remaining enzymes of the supernatant fraction decreased at both time intervals. The response of the activities of aconitase, fumarase and ATP-ase 2 hr after injection were the opposite of those at 8 hr. The results are explicable in terms of mitochondrial injury of the aflatoxin-treated animals.
在注射毒素2小时后，研究了单剂量黄曲霉毒素对小鼠肝脏糖原、脂质和蛋白质含量的影响，但未观察到显著变化。在黄曲霉毒素处理后2小时和8小时测定小鼠肝脏中的酶。一般来说，微粒体部分的酶和上清液中的异柠檬酸脱氢酶显著增加；上清液部分的其余酶在两个时间间隔均下降。注射后2小时乌头酸酶、延胡索酸酶和ATP酶活性的反应与8小时时相反。这些结果可以用黄曲霉毒素处理动物的线粒体损伤来解释。
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