黄曲霉毒素B1对吡啶核苷酸和NADP连接的脱氢酶的影响。
Effect of aflatoxin B1 on pyridine nucleotides and NADP linked dehydrogenases.
作者信息
Singh N, Venkitasubramanian T A
出版信息
Br J Exp Pathol. 1975 Oct;56(5):423-8.
The effect of a single interaperitoneal injection (6 mg/kg body weight) of aflatoxin B1 in propylene glycol on pyridine nucleotides and NDP linked dehydrogenases was studied 24 h after administration of the toxin. The liver showed a decrease in total proteins and pyridine nucleotides though levels of NADP and NADPH remained unchanged. Levels of NAD and NADH were decreased. The activities of hepatic of hwpRIX of hepatic malate dehydrogenase (MDH) and isocitrate dehydrogenase (ICDH) were not altered though ICDH showed an increase when expressed on protein basis. However, there was a significance decrease in the activity of combined HMP dehydrogenases. Adipose tissue showed increased activities of the HMP dehydrogenasess.
研究了在丙二醇中腹腔注射一次黄曲霉毒素B1（6毫克/千克体重）对毒素给药24小时后吡啶核苷酸和NDP连接的脱氢酶的影响。肝脏中总蛋白和吡啶核苷酸减少，尽管NADP和NADPH水平保持不变。NAD和NADH水平降低。肝苹果酸脱氢酶（MDH）和异柠檬酸脱氢酶（ICDH）的肝脏hwpRIX活性未改变，尽管以蛋白为基础表达时ICDH有所增加。然而，联合HMP脱氢酶的活性有显著降低。脂肪组织中HMP脱氢酶的活性增加。
Zotero 插件