Ashida S I, Abiko Y
Thromb Haemost. 1979 Feb 15;40(3):542-50.
Effect of Ticlopidine, 5-(2-chlorobenzyl)-4, 5, 6, 7-tetrahydro[3,2-C]pyridine hydro-chloride, on platelet aggregation was studied in the rat. Ticlopidine was found to be a potent, long-lasting inhibitor of platelet aggregation. It inhibited the aggregation induced by any of ADP, collagen, thrombin, arachidonic acid and prostaglandin endoperoxides and/or thromboxane A2-like substancee. Ticlopidine was effective at doses as low as 30 mg/kg when orally given to rats, and the effect lasted as long as the life span of the circulating platelets (half time: about 48 hours). Ticlopidine inhibited also nucleotide release from and prostaglandin synthesis in the platelets, but did not significantly affect platelet adhesiveness to glass, platelet factor 3 availability and clot retraction.
研究了盐酸噻氯匹定（5 - (2 - 氯苄基)-4,5,6,7 - 四氢[3,2 - C]吡啶盐酸盐）对大鼠血小板聚集的影响。发现噻氯匹定是一种强效、持久的血小板聚集抑制剂。它能抑制由二磷酸腺苷（ADP）、胶原、凝血酶、花生四烯酸和前列腺素内过氧化物及/或血栓素A2样物质中的任何一种所诱导的聚集。当给大鼠口服低至30mg/kg剂量的噻氯匹定时就有效果，且该作用持续时间与循环血小板的寿命一样长（半衰期：约48小时）。噻氯匹定还抑制血小板中的核苷酸释放和前列腺素合成，但对血小板与玻璃的黏附性、血小板因子3的可用性及血块回缩没有显著影响。
