Chernikov M P, Nikolaevskaia V R, Stan E Ia
Vopr Med Khim. 1979 Jan-Feb;25(1):67-71.
Activities of trypsin and chymotrypsin were studied in pancreas as well as in chyme from three departments of small intestine of rats of various age. Distinct decrease in content of chymotrypsinogen and increase in content of trypsinogen were observed in pancreas at first four days of rat life. In pancreas content of trypsinogen and chymotrypsinogen was as high in 4--20 days old rats as that one in 30-days old animals, maintained at definitive diet. Activity of trypsin and chymotrypsin was the same in duodenal contents of rats of both these groups. Activity of pancreatic proteinases was almost unaltered in chyme of jejunum intestine within first 20 days of life; it was twice increased to 30-days age. Trypsin and chymotrypsin were distinctly activated in chyme of ileum intestine with ageing. The highest activity of pancreatic proteinases was observed in chyme of ileum intestine. The data obtained suggest that rather intensive cavitary digestion of milk protein occurs in newborn rats.
研究了不同年龄大鼠胰腺以及小肠三个部位食糜中胰蛋白酶和糜蛋白酶的活性。在大鼠出生后的前四天，胰腺中糜蛋白酶原含量明显降低，胰蛋白酶原含量增加。在4 - 20日龄大鼠的胰腺中，胰蛋白酶原和糜蛋白酶原的含量与维持确定饮食的30日龄动物相同。这两组大鼠十二指肠内容物中胰蛋白酶和糜蛋白酶的活性相同。在生命的前20天内，空肠食糜中胰腺蛋白酶的活性几乎没有变化；到30日龄时增加了两倍。随着年龄增长，回肠食糜中的胰蛋白酶和糜蛋白酶被明显激活。在回肠食糜中观察到胰腺蛋白酶的活性最高。所获得的数据表明，新生大鼠对乳蛋白进行了相当强烈的腔内消化。
