Nikolaevskaia V R, Chernikov M P
Biull Eksp Biol Med. 1979 Oct;88(10):393-5.
The proteolytic activity of lysosomal and pancreatic proteinases was studied in the chyme and tissue homogenates of the jejunum and ileum of 12- and 30-day rats in order to elucidate whether lysosomal proteinases of the mucous membrane of the ileum participate in cavitary digestion. During milk feeding the proteolytic activity of acid (lysosomal) proteinases in the ileum was 3 times greater than in the jejunum, which has been demonstrated both for the mucous membrane and the contents of these parts of the small intestine. In rats on definitive nutrition the activity of acid proteinases from the jejunum and ileum remained almost unchanged both in the mucous membrane and in the contents. The data obtained also indicate that pancreatic proteinase absorbed from the chyme of the small intestine may participate in parietal digestion.
为了阐明回肠黏膜的溶酶体蛋白酶是否参与腔消化，对12日龄和30日龄大鼠空肠和回肠的食糜及组织匀浆中的溶酶体和胰腺蛋白酶的蛋白水解活性进行了研究。在哺乳期间，回肠中酸性（溶酶体）蛋白酶的蛋白水解活性比空肠高3倍，这在小肠这些部位的黏膜和内容物中均得到了证实。在给予确定营养的大鼠中，空肠和回肠酸性蛋白酶在黏膜和内容物中的活性几乎保持不变。所获得的数据还表明，从小肠食糜中吸收的胰腺蛋白酶可能参与壁内消化。
