[Determination of fibrinogen concentration in blood plasma by the sulfite precipitation method].

Two methods using thrombine and sulfite were compared for estimation of fibrinogen concentration in blood plasma. Both methods produced the same results in estimation of fibrinogen in donor blood plasma. If blood plasma contained high amount of products of fibrinogen and/or fibrin degradation, the efficiency of thrombin method was decreased; on the other hand, final concentration of sulfite did not precipitate fragment D of fibrinogen from human blood plasma. Presence of heparin did not influence on the sulfite method but the polysaccharide might interfere in the thrombin method. Some experiments require to use both these methods for evaluation of fibrinogen in blood plasma.