离子对纺锤体适应性的影响。
Ionic effects on spindle adaptation.
作者信息
Husmark I, Ottoson D
出版信息
J Physiol. 1971 Oct;218(2):257-69. doi: 10.1113/jphysiol.1971.sp009616.
Abstract
- Effects of changes in ionic environment on the receptor potential were studied in isolated frog spindle. Particular attention was focused on the action of potassium removal on the early adaptive decline of the response.2. Removal of potassium caused a reduction and final disappearance of the dynamic overshoot of the receptor potential. The static phase of the response was also reduced although to less extent. The repolarization phase of the response following release of phasic or maintained stretch was greatly prolonged.3. Increased potassium concentration caused a reduction of the response, but did not change its general time course. The amount of reduction was related to the potassium concentration.4. Removal of sodium caused a marked diminution of the response, the static phase being in general more affected than the dynamic phase.5. It is suggested that the effects of potassium removal are caused by a delay in sodium inactivation and a partial depolarization of the endings. It is concluded that the greater part of the early adaptation of the spindle proper may be attributed to ionic mechanisms in the transducer membrane.
摘要
在离体蛙纺锤体中研究了离子环境变化对感受器电位的影响。特别关注了去除钾对反应早期适应性下降的作用。
去除钾导致感受器电位的动态超射降低并最终消失。反应的静态阶段也有所降低，尽管程度较小。在相位或持续拉伸释放后反应的复极化阶段大大延长。
增加钾浓度导致反应降低，但不改变其总体时间进程。降低的程度与钾浓度有关。
去除钠导致反应明显减弱，静态阶段通常比动态阶段受影响更大。
有人认为，去除钾的作用是由钠失活延迟和末梢部分去极化引起的。得出的结论是，纺锤体本身早期适应性的大部分可能归因于换能器膜中的离子机制。
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本文引用的文献
1
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Science. 1963 Aug 23;141(3582):716-7. doi: 10.1126/science.141.3582.716.
2
Depolarization of sensory terminals and the initiation of impulses in the muscle spindle.感觉末梢的去极化以及肌梭中冲动的起始。
J Physiol. 1950 Oct 16;111(3-4):261-82. doi: 10.1113/jphysiol.1950.sp004479.
3
THE ACTION OF CALCIUM ON THE FROG'S ISOLATED MUSCLE SPINDLE.钙对青蛙离体肌梭的作用
J Physiol. 1965 May;178(1):68-79. doi: 10.1113/jphysiol.1965.sp007614.
4
THE EFFECT OF DILUTING THE INTERNAL SOLUTION ON THE ELECTRICAL PROPERTIES OF A PERFUSED GIANT AXON.稀释内部溶液对灌流巨型轴突电特性的影响。
J Physiol. 1964 Apr;170(3):541-60. doi: 10.1113/jphysiol.1964.sp007348.
5
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J Physiol. 1963 Nov;169(1):91-115. doi: 10.1113/jphysiol.1963.sp007243.
6
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Proc Natl Acad Sci U S A. 1962 Sep 15;48(9):1571-7. doi: 10.1073/pnas.48.9.1571.
7
Potassium permeability in myelinated nerve fibres of Xenopus laevis.非洲爪蟾有髓神经纤维中的钾通透性。
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8
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