Viktorov I V, Bunina T L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(2):169-71.
Organotypical cultures of the spinal cord of the fetal mouse were used to study the neurocytotoxic effect of sera from patients with amyotrophic lateral sclerosis (ALS). Sera from 16 patients with ALS were used in two experiments: 1. short-term treatment (up to 6 days) of the mature cultures with nutrient medium containing 30% of ALS serum; 2. long-term cultivation from the explantation up to 4 weeks of spinal cord in the medium containing 5-25% of ALS serum. No specific neurotoxic effect of ALS sera on the motor neurons of the cultured spinal cord were observed in acute or chronic experiments.
使用胎鼠脊髓的器官型培养物来研究肌萎缩侧索硬化症（ALS）患者血清的神经细胞毒性作用。在两个实验中使用了16例ALS患者的血清：1. 用含有30% ALS血清的营养培养基对成熟培养物进行短期处理（长达6天）；2. 在含有5-25% ALS血清的培养基中，从脊髓外植开始进行长达4周的长期培养。在急性或慢性实验中，均未观察到ALS血清对培养脊髓运动神经元有特异性神经毒性作用。
