Viktorov I V, Bunina T L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(7):984-90.
In order to study the myelinotoxicity of the blood serum in patients with lateral amyotrophical sclerosis the authors used myelinated explants of the spinal cord of mice embryo. A total amount of 17 blood sera of patients with lateral amyotrophical sclerosis was studied. It was demonstrated that the serum of such patients introduced into nourishing medium in a concentration of 25% does not lead to an expressed demyelination of the nervous fibres. Cultivation of the spinal cord in a medium, containing 5--25% of the patient sera from the moment of explanation does not influence the process of myeline sheath formation. These data indicate that the serum of patients with lateral amyotrophical sclerosis do not possess myelinotoxic and myelininhibiting properties.
为了研究侧索肌萎缩硬化症患者血清的髓鞘毒性，作者使用了小鼠胚胎脊髓的有髓外植体。研究了17份侧索肌萎缩硬化症患者的血清。结果表明，将此类患者的血清以25%的浓度引入营养培养基中，不会导致神经纤维出现明显的脱髓鞘现象。从植入时刻起，在含有5%-25%患者血清的培养基中培养脊髓，不会影响髓鞘形成过程。这些数据表明，侧索肌萎缩硬化症患者的血清不具有髓鞘毒性和髓鞘抑制特性。
