某些代谢活性变化与深层麦角菌生物碱产生之间的相关性
Correlation of certain alterations in metabolic activity with alkaloid production by submerged Claviceps.
作者信息
Rehácek Z, Sajdl P, Kozová J, Malik K A, Ricicová A
出版信息
Appl Microbiol. 1971 Dec;22(6):949-56. doi: 10.1128/am.22.6.949-956.1971.
Abstract
Alkaloid biosynthesis in Claviceps paspali MG-6 was favored by unbalanced growth. A positive correlation between the rate of protein turnover and alkaloid formation was noted. The pattern of the orthophosphate content in the mycelium resembled that in the ripening sclerotia of the parasitic strains. Alkaloids were revealed as potentially effective in energy metabolism. Reduced adenosine triphosphate (ATP) utilization and an increase in the ATP pool were found to be favorable for alkaloid production. Acetyl-coenzyme A carboxylase activity and the level of cell lipids were directly related to the intensity of alkaloid biosynthesis. An inverse relationship was observed between the activities of the tricarboxylic acid and glycoxylate cycles and the rate of alkaloid formation.
摘要
不平衡生长有利于雀稗麦角菌MG-6中生物碱的生物合成。蛋白质周转速率与生物碱形成之间存在正相关关系。菌丝体中正磷酸盐含量的模式与寄生菌株成熟菌核中的相似。生物碱被发现对能量代谢具有潜在作用。发现降低三磷酸腺苷（ATP）的利用并增加ATP库有利于生物碱的产生。乙酰辅酶A羧化酶活性和细胞脂质水平与生物碱生物合成的强度直接相关。观察到三羧酸循环和乙醛酸循环的活性与生物碱形成速率之间呈负相关关系。
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