生物素对麦角菌属菌株SD-58深层培养过程中生物碱产生的影响。
Effect of biotin on alkaloid production during submerged cultivation of Claviceps sp. strain SD-58.
作者信息
Desai J D, Desai A J, Patel H C
出版信息
Appl Environ Microbiol. 1983 May;45(5):1694-6. doi: 10.1128/aem.45.5.1694-1696.1983.
Abstract
Addition of biotin to culture medium NL-406 significantly increased alkaloid yield during submerged cultivation of Claviceps sp. strain SD-58. Alkaloid yield was further enhanced by incorporating leucine in biotin-supplemented culture medium. Increased alkaloid production was associated with an increase in the lipid content of cells and in the number of chlamydospores. Biotin deficiency caused a reduction in alkaloid yield and a parallel decrease in lipid content and chlamydospore numbers.
摘要
在培养基NL - 406中添加生物素可显著提高麦角菌属菌株SD - 58深层培养过程中的生物碱产量。在添加生物素的培养基中加入亮氨酸可进一步提高生物碱产量。生物碱产量的增加与细胞脂质含量和厚垣孢子数量的增加有关。生物素缺乏导致生物碱产量降低，同时脂质含量和厚垣孢子数量也相应减少。
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