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Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism.

作者信息

Breyer U

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1972;272(3):277-88. doi: 10.1007/BF00499039.

DOI:10.1007/BF00499039
PMID:4258613
Abstract
摘要

相似文献

1
Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism.奋乃静、氯丙嗪和丙咪嗪作为微粒体药物代谢诱导剂。
Naunyn Schmiedebergs Arch Pharmacol. 1972;272(3):277-88. doi: 10.1007/BF00499039.
2
Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.由于用苯巴比妥和氯丙嗪处理哺乳期母鼠，导致乳鼠肝脏中药物代谢活性的变化。
Biochem J. 1971 Mar;122(1):41-7. doi: 10.1042/bj1220041.
3
Effects of dietary protein quality on drug metabolism in the rat.膳食蛋白质质量对大鼠药物代谢的影响。
J Nutr. 1973 Oct;103(10):1425-30. doi: 10.1093/jn/103.10.1425.
4
Drug metabolism by hepatic microsomes from phenobarbital-treated or starved male and female rats in the presence of inhibitors.
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5
[Effect of a series of phenothiazines on the NADH cytochrome c-reductase activity of liver microsomes].[一系列吩噻嗪类药物对肝微粒体NADH细胞色素c还原酶活性的影响]
C R Acad Hebd Seances Acad Sci D. 1971 Dec 20;273(25):2668-70.
6
Comparison of microsomal drug hydroxylation in lung and liver of various species.不同物种肺和肝脏中微粒体药物羟基化作用的比较。
Res Commun Chem Pathol Pharmacol. 1970 Jan;1(1):43-56.
7
Effect of suramin (Bayer 205) on hepatic microsomal cytochromes P-450, b 5 , and demethylation activity in rats.苏拉明（拜耳205）对大鼠肝微粒体细胞色素P - 450、b5及去甲基化活性的影响
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Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats.
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Species and substrate differences of liver microsomal N-dealkylation and N-oxidation of tertiary amines and N-dealkylation of N-oxides.肝脏微粒体中叔胺的N-脱烷基化和N-氧化以及N-氧化物的N-脱烷基化的物种和底物差异。
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Effect of enzyme inducers on substrate specificity of the cytochrome P-450's.酶诱导剂对细胞色素P-450底物特异性的影响。
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Cerebral pharmacokinetics of imipramine in rats after single and multiple dosages.单次及多次给药后大鼠体内丙咪嗪的脑药代动力学
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Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.长期给予受体研究中所用剂量后，对大鼠血浆和脑内游离及总阿米替林及其代谢物水平的评估。
Psychopharmacology (Berl). 1984;84(4):489-95. doi: 10.1007/BF00431455.
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The effect of imipramine and desipramine on mixed function oxidase in rats.

本文引用的文献

1
DRUG INTERACTIONS IN MAN. I. LOWERING EFFECT OF PHENOBARBITAL ON PLASMA LEVELS OF BISHYDROXYCOUMARIN (DICUMAROL) AND DIPHENYLHYDANTOIN (DILANTIN).人体中的药物相互作用。I. 苯巴比妥对双香豆素（双香豆素）和苯妥英（大仑丁）血浆水平的降低作用。
Clin Pharmacol Ther. 1965 Jul-Aug;6:420-9. doi: 10.1002/cpt196564420.
2
EFFECTS OF PHENOTHIAZINES ON PROTECTIVE SYSTEMS AGAINST POLYCYCLIC HYDROCARBONS.吩噻嗪对多环烃防护系统的影响
Cancer Res. 1965 Apr;25:365-70.
3
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
丙咪嗪和去甲丙咪嗪对大鼠混合功能氧化酶的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):83-6. doi: 10.1007/BF00496111.
4
Stimulation of drug metabolism in man by tricyclic antidepressants.三环类抗抑郁药对人体药物代谢的刺激作用。
Eur J Clin Pharmacol. 1973 Aug;6(2):102-6. doi: 10.1007/BF00562435.
5
Ultrastructural and biochemical study of the action of benzoctamine and maprotiline on the rat liver.苯辛胺和马普替林对大鼠肝脏作用的超微结构及生化研究
Agents Actions. 1974 Dec;4(5):391-403. doi: 10.1007/BF01964942.
6
Bioavailability of hetacillin in rats after liver enzyme induction by various inducers with or without protein binding properties.
Eur J Drug Metab Pharmacokinet. 1985 Jan-Mar;10(1):27-32. doi: 10.1007/BF03189694.
7
Metabolic interaction between imipramine and carbamazepine in vivo and in vitro in rats.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):105-10. doi: 10.1007/BF00169485.
8
Single-dose kinetics of the neuroleptic drug perazine in psychotic patients.
Psychopharmacology (Berl). 1988;95(3):374-7. doi: 10.1007/BF00181950.
9
Effect of enzyme induction on bioavailability of hetacillin in patients treated with anticonvulsants and chlorpromazine.
Eur J Drug Metab Pharmacokinet. 1990 Jan-Mar;15(1):15-8. doi: 10.1007/BF03190122.
10
Alteration of cytochrome P-450 by prolonged administration of imipramine and/or lithium to rats.长期给大鼠服用丙咪嗪和/或锂对细胞色素P-450的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1990 Aug;342(2):234-40. doi: 10.1007/BF00166970.
肝微粒体的一氧化碳结合色素。I. 其血红蛋白性质的证据。
J Biol Chem. 1964 Jul;239:2370-8.
4
FURTHER STUDIES ON THE INHIBITION AND STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYMES OF RAT LIVER BY VARIOUS COMPOUNDS.多种化合物对大鼠肝脏微粒体药物代谢酶的抑制与刺激作用的进一步研究
Biochem Pharmacol. 1964 Jan;13:69-83. doi: 10.1016/0006-2952(64)90080-2.
5
The metabolism and excretion of S35-chlorpromazine by the rat.大鼠对S35-氯丙嗪的代谢与排泄
J Pharmacol Exp Ther. 1962 Aug;137:148-55.
6
Demethylation of chlorpromazine-(N-methyl)-C14.氯丙嗪 -（N - 甲基）-C14的去甲基化作用
Science. 1958 Nov 21;128(3334):1279-80. doi: 10.1126/science.128.3334.1279.
7
The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.通过汉茨希反应对比色法测定甲醛。
Biochem J. 1953 Oct;55(3):416-21. doi: 10.1042/bj0550416.
8
Microsomal oxidases. II. Properties of a pork liver microsomal N-oxide dealkylase.
Biochemistry. 1966 Sep;5(9):2939-43. doi: 10.1021/bi00873a025.
9
Researches on the increase of liver weight produced by some drugs.关于某些药物导致肝脏重量增加的研究。
Biochem Pharmacol. 1966 Mar;15(3):249-54. doi: 10.1016/0006-2952(66)90295-4.
10
Inter-patient variation in chlorpromazine metabolism.氯丙嗪代谢的患者间差异。
Exp Med Surg. 1965;23(2):278-87.