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由于用苯巴比妥和氯丙嗪处理哺乳期母鼠，导致乳鼠肝脏中药物代谢活性的变化。

Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.

作者信息

Darby F J

出版信息

Biochem J. 1971 Mar;122(1):41-7. doi: 10.1042/bj1220041.

DOI:10.1042/bj1220041
PMID:5166400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1176685/
Abstract
  1. Lactating female rats were treated with phenobarbitone or chlorpromazine. 2. Hepatic microsomal fractions from the suckling offspring were studied to see if changes had occurred in the rates of drug metabolism. 3. Treatment with phenobarbitone significantly increased the cytochrome P-450 concentration, the activity of NADPH-cytochrome c reductase (EC 1.6.2.3) and the rates of metabolism of aniline, ethylmorphine and [2-(14)C]pentobarbitone. 4. Treatment with chlorpromazine produced only small increases in the cytochrome P-450 concentration and the rate of hydroxylation of aniline.
摘要
  1. 给哺乳期雌性大鼠注射苯巴比妥或氯丙嗪。2. 研究了哺乳后代肝脏微粒体部分，以观察药物代谢速率是否发生变化。3. 用苯巴比妥治疗显著增加了细胞色素P - 450浓度、NADPH - 细胞色素c还原酶（EC 1.6.2.3）的活性以及苯胺、乙基吗啡和[2 -（14）C]戊巴比妥的代谢速率。4. 用氯丙嗪治疗仅使细胞色素P - 450浓度和苯胺羟化速率有小幅增加。

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1
Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.由于用苯巴比妥和氯丙嗪处理哺乳期母鼠，导致乳鼠肝脏中药物代谢活性的变化。
Biochem J. 1971 Mar;122(1):41-7. doi: 10.1042/bj1220041.
2
Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism.奋乃静、氯丙嗪和丙咪嗪作为微粒体药物代谢诱导剂。
Naunyn Schmiedebergs Arch Pharmacol. 1972;272(3):277-88. doi: 10.1007/BF00499039.
3
Possible role of P-450 in the oxidation of drugs in liver microsomes.P - 450在肝微粒体中药物氧化过程中的可能作用。
J Biochem. 1966 Jun;59(6):574-83. doi: 10.1093/oxfordjournals.jbchem.a128346.
4
Influence of dietary thiamin on phenobarbital induction of rat hepatic enzymes responsible for metabolizing drugs and carcinogens.膳食硫胺素对苯巴比妥诱导大鼠肝脏中负责代谢药物和致癌物的酶的影响。
Drug Nutr Interact. 1983;2(2):117-30.
5
Inhibition by ethylmorphine and pentobarbitone in vitro of the metabolism of (ureyl- 14 C)tolbutamide by hepatic microsomal preparations from male and female rats treated with phenobarbitone.苯巴比妥处理的雄性和雌性大鼠肝微粒体制剂对（脲基-¹⁴C）甲苯磺丁脲代谢的体外抑制作用：乙基吗啡和戊巴比妥的影响
Biochem Pharmacol. 1972 Jun 1;21(11):1649-56. doi: 10.1016/0006-2952(72)90315-2.
6
Inhibition by ethylmorphine and pentobarbitone in vitro of the metabolism of (ureyl- 14 C)tolbutamide by hepatic microsomal preparations from sexually-immature male and female rats treated with phenobarbitone.用苯巴比妥处理的未成熟雄性和雌性大鼠的肝微粒体制剂在体外，乙基吗啡和戊巴比妥对（脲基-14C）甲苯磺丁脲代谢的抑制作用。
Biochem Pharmacol. 1973 Apr 15;22(8):989-92. doi: 10.1016/0006-2952(73)90225-6.
7
Increase of pentobarbitone metabolism induced in rats pretreated with some centrally acting compounds.用某些中枢作用化合物预处理的大鼠中戊巴比妥代谢的增加。
Br J Pharmacol Chemother. 1962 Feb;18(1):29-38. doi: 10.1111/j.1476-5381.1962.tb01147.x.
8
Influence of the oral contraceptive, menstranol, on drug-metabolizing enzymes of female rats in thiamin-supplemented and deficiency states.口服避孕药炔雌醇甲醚对硫胺素补充和缺乏状态下雌性大鼠药物代谢酶的影响。
Pharmacology. 1976;14(2):104-14. doi: 10.1159/000136586.
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Comparison of microsomal drug hydroxylation in lung and liver of various species.不同物种肺和肝脏中微粒体药物羟基化作用的比较。
Res Commun Chem Pathol Pharmacol. 1970 Jan;1(1):43-56.
10
Sex and strain differences in basal and induced aniline hydroxylase and ethylmorphine N-demethylase activities from domestic and wild rats.家鼠和野鼠中基础及诱导型苯胺羟化酶和N-脱甲基乙吗啡酶活性的性别及品系差异
Pharmacology. 1969;2(6):321-36. doi: 10.1159/000136037.

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Environmental influences on human foetal and placental xenobiotic metabolism.环境对人类胎儿及胎盘外源性物质代谢的影响。
Eur J Clin Pharmacol. 1980 Jul;18(1):17-24. doi: 10.1007/BF00561474.
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Induction of peroxisomal enzymes in livers of neonatal rats exposed to lactating mothers treated with hypolipidaemic drugs. Role of drug metabolite transfer in milk.用降血脂药物治疗的哺乳期母鼠所哺育的新生大鼠肝脏中过氧化物酶体酶的诱导。药物代谢产物在乳汁中的转移作用。
Biochem J. 1983 Mar 15;210(3):875-83. doi: 10.1042/bj2100875.
3
The metabolism in vitro of (ureyl-14C)-tolbutamide by microsomal preparations from rat and human liver.大鼠和人肝脏微粒体制剂对（脲基-14C）甲苯磺丁脲的体外代谢
Biochem J. 1971 Nov;125(2):46P-47P. doi: 10.1042/bj1250046pb.
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J Exp Med. 1971 Nov 1;134(5):1349-71. doi: 10.1084/jem.134.5.1349.
5
Glutathione S-aryltransferase: the effect of treating male and female rats with phenobarbitone on the apparent kinetic parameters for the conjugation of 1,2-dichloro-4-nitrobenzene and 1-chloro-2,4-dinitrobenzene with glutathione.谷胱甘肽S-芳基转移酶：用苯巴比妥处理雄性和雌性大鼠对1,2-二氯-4-硝基苯和1-氯-2,4-二硝基苯与谷胱甘肽结合的表观动力学参数的影响。
Biochem J. 1972 Jun;128(1):175-7. doi: 10.1042/bj1280175.
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Nasal secretion in the cat.猫的鼻分泌物
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本文引用的文献

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Induction of drug-metabolizing enzymes in liver microsomes of mice and rats by softwood bedding.软木垫料对小鼠和大鼠肝微粒体药物代谢酶的诱导作用。
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FURTHER STUDIES ON THE INHIBITION AND STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYMES OF RAT LIVER BY VARIOUS COMPOUNDS.多种化合物对大鼠肝脏微粒体药物代谢酶的抑制与刺激作用的进一步研究
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Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.肝脏微粒体三磷酸吡啶核苷酸-细胞色素c还原酶
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Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine.大鼠长期给予吗啡、烯丙吗啡和去甲吗啡后的生化及药理变化。
J Pharmacol Exp Ther. 1959 Feb;125(2):105-10.
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The chromatographic behaviour of cytochrome c on cation exchangers.细胞色素c在阳离子交换剂上的色谱行为。
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