由于用苯巴比妥和氯丙嗪处理哺乳期母鼠，导致乳鼠肝脏中药物代谢活性的变化。
Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.
作者信息
Darby F J
出版信息
Biochem J. 1971 Mar;122(1):41-7. doi: 10.1042/bj1220041.
Abstract
- Lactating female rats were treated with phenobarbitone or chlorpromazine. 2. Hepatic microsomal fractions from the suckling offspring were studied to see if changes had occurred in the rates of drug metabolism. 3. Treatment with phenobarbitone significantly increased the cytochrome P-450 concentration, the activity of NADPH-cytochrome c reductase (EC 1.6.2.3) and the rates of metabolism of aniline, ethylmorphine and [2-(14)C]pentobarbitone. 4. Treatment with chlorpromazine produced only small increases in the cytochrome P-450 concentration and the rate of hydroxylation of aniline.
摘要
- 给哺乳期雌性大鼠注射苯巴比妥或氯丙嗪。2. 研究了哺乳后代肝脏微粒体部分，以观察药物代谢速率是否发生变化。3. 用苯巴比妥治疗显著增加了细胞色素P - 450浓度、NADPH - 细胞色素c还原酶（EC 1.6.2.3）的活性以及苯胺、乙基吗啡和[2 -（14）C]戊巴比妥的代谢速率。4. 用氯丙嗪治疗仅使细胞色素P - 450浓度和苯胺羟化速率有小幅增加。
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