Gibbs H C, Gupta R P
Can J Comp Med. 1972 Apr;36(2):108-15.
Tests were carried out on the efficacy of Cambendazole (5-isopropoxy carbonylamino-2-(4-thiazolyl) benzimidazole) against lungworm and gastrointestinal parasites of calves and lambs. Against Dictyocaulus viviparus the compound was highly effective (80%) against mature worms at levels of 35 mg/kg and over and immature "arrested" worms at 60 mg/kg (71% efective). In the Calves the compound was very effective (90 to 99%) against adult Haemonchus placei, Ostertagia spp., Trichostrongylus axei and Cooperia oncophora at all levels tested (15, 20, 25, 30, 40 and 60 mg/kg). Against adult Nematodirus spp. dosages of 30, 40 and 60 mg/kg were 81%, 94% and 99% effective respectivelyAgainst arrested Ostertagia spp. larvae, a dosage of 60 mg/kg was 90% effective. Immature stages of Cooperia spp. were susceptible at all levels used but those of Nematodirus spp. required levels of 60 mg/kg for 99% removal. In the lambs the compound was highly effective against immature and mature nematodes when given orally at all levels tested from 15 mg/kg to 30 mg/kg. Significant reductions (81%) in Moniezia expansa scolices were also observed at dosages from 15 mg/kg to 30 mg/kg.
对坎苯达唑（5 - 异丙氧基羰基氨基 - 2 -（4 - 噻唑基）苯并咪唑）对犊牛和羔羊肺线虫及胃肠道寄生虫的疗效进行了试验。对于胎生网尾线虫，该化合物在35毫克/千克及以上剂量时对成熟虫体高效（80%），在60毫克/千克时对未成熟的“停滞”虫体有效（71%有效）。在犊牛中，该化合物在所有测试剂量（15、20、25、30、40和60毫克/千克）下对成年的夏伯特线虫、奥斯特他线虫属、艾氏毛圆线虫和哥伦比亚食道口线虫都非常有效（90%至99%）。对于成年的细颈线虫属，30、40和60毫克/千克的剂量分别有81%、94%和99%的效果。对于停滞的奥斯特他线虫属幼虫，60毫克/千克的剂量有90%的效果。哥伦比亚食道口线虫的未成熟阶段在所有使用剂量下都易感，但细颈线虫属的未成熟阶段需要60毫克/千克的剂量才能99%清除。在羔羊中，当以15毫克/千克至30毫克/千克的所有测试剂量口服给药时，该化合物对未成熟和成熟线虫都非常有效。在15毫克/千克至30毫克/千克的剂量下，还观察到扩展莫尼茨绦虫头节数量显著减少（81%）。
