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Decarboxylation of orally administered L-dopa in the human digestive tract.

作者信息

Bergmark J, Carlsson A, Granerus A K, Jagenburg R, Magnusson T, Svanborg A

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1972;272(4):437-40. doi: 10.1007/BF00501249.

DOI:10.1007/BF00501249
PMID:4260263
Abstract
摘要

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1
Decarboxylation of orally administered L-dopa in the human digestive tract.
Naunyn Schmiedebergs Arch Pharmacol. 1972;272(4):437-40. doi: 10.1007/BF00501249.
2
Intestinal decarboxylation of L-Dopa in relation to dose requirement in Parkinson's disease.
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L-dopa level in plasma, primary condition for the kinetic effect.血浆中左旋多巴水平，这是动力学效应的首要条件。
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Metabolism of levodopa in patients with Parkinson's disease. Radioactive and fluorometric assays.帕金森病患者中左旋多巴的代谢。放射性和荧光测定法。
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本文引用的文献

1
Drug-induced changes of extracerebral dopa metabolism in man.
Arch Neurol. 1969 Feb;20(2):187-90. doi: 10.1001/archneur.1969.00480080087010.
2
L-3,4-dihydroxyphenylalanine metabolism by the gut in vitro.
Biochem Pharmacol. 1971 Nov;20(11):3051-7. doi: 10.1016/0006-2952(71)90109-2.
帕金森病中的刺蒺藜豆：一项双盲临床与药理学研究。
J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1672-7. doi: 10.1136/jnnp.2003.028761.
4
The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.通过人体空肠区域灌注研究L-亮氨酸对左旋多巴吸收的影响。
Br J Clin Pharmacol. 1993 Mar;35(3):243-50. doi: 10.1111/j.1365-2125.1993.tb05691.x.
5
Intestinal decarboxylation of L-Dopa in relation to dose requirement in Parkinson's disease.
Naunyn Schmiedebergs Arch Pharmacol. 1973;280(4):429-39. doi: 10.1007/BF00506633.
6
Clinical pharmacokinetics of anti-parkinsonian drugs.抗帕金森病药物的临床药代动力学
Clin Pharmacokinet. 1987 Sep;13(3):141-78. doi: 10.2165/00003088-198713030-00002.
7
The role of the liver in the clearance of l-dope from plasma.
J Pharmacokinet Biopharm. 1975 Feb;3(1):13-23. doi: 10.1007/BF01066592.
8
Levodopa and decarboxylase inhibitors: a review of their clinical pharmacology and use in the treatment of parkinsonism.左旋多巴与脱羧酶抑制剂：其临床药理学及在帕金森病治疗中的应用综述
Drugs. 1976;11(5):329-77. doi: 10.2165/00003495-197611050-00001.