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狒狒急性情绪状态下的肾脏和后肢血管控制

Renal and hindlimb vascular control during acute emotion in the baboon.

作者信息

Smith O A, Hohimer A R, Astley C A, Taylor D J

出版信息

Am J Physiol. 1979 Mar;236(3):R198-205. doi: 10.1152/ajpregu.1979.236.3.R198.

DOI:10.1152/ajpregu.1979.236.3.R198
PMID:426096
Abstract

Blood pressure, heart rate, oxygen consumption, and blood flow to the renal and hind-limb vasculatures were measured in healthy, unanesthetized baboons (Papio cynocephalus) in a controlled environment. Appropriate behavioral techniques were applied to allow the reproducible elicitation of a conditional emotional response (CER). Section of renal nerves and autonomic pharmacologic interventions were used to determine the mechanisms for the cardiovascular responses accompanying the CER. The resistance changes in the renal and hind-limb vascular beds were generated by rapid, neurally mediated vasoconstriction of the renal vasculature and by a slower acting, circulating vasoactive agent, most probably epinephrine, which causes a delayed second constriction in the renal bed and a net dilation in the hind limbs.

摘要

在可控环境中,对健康、未麻醉的狒狒(Papio cynocephalus)测量其血压、心率、耗氧量以及肾和后肢血管系统的血流量。应用适当的行为技术以可重复地诱发条件性情绪反应(CER)。通过切断肾神经和进行自主神经药理学干预来确定伴随CER的心血管反应机制。肾血管床和后肢血管床的阻力变化是由肾血管系统快速的神经介导血管收缩以及一种作用较慢的循环血管活性物质(很可能是肾上腺素)引起的,肾上腺素会导致肾床延迟出现第二次收缩,并使后肢出现净扩张。

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Renal and hindlimb vascular control during acute emotion in the baboon.狒狒急性情绪状态下的肾脏和后肢血管控制
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