Williams D B, Karl R C
Am J Surg. 1979 Apr;137(4):572-6. doi: 10.1016/0002-9610(79)90133-8.
Warfarin anticoagulation data from forty-seven patients studied retrospectively was used to develop an algorithm for predicting daily maintenance dose of warfarin. A plot of prothrombin time versus cumulative warfarin loading dose was made for each of the forty-seven patients and the aera under the curve (AREA) measured from the baseline prothrombin time to a prothrombin time of 20 seconds. A linear correlation between the established daily maintenance dose of warfarin and AREA was derived regression analysis: Daily maintenance dose (mg/day) = 0.0465 x (AREA) + 1.5. The correlation was then used to predict daily maintenance dose in twenty-four patients studied prospectively. The mean prothrombin time for a seven day stabilization period after loading for all patients in the prospective study was 21.5 +/- 2.2 seconds and the seven day mean prothrombin time for each patient fell between 19 and 24 seconds. The results of the prospective study indicate that this technic is useful in the early, accurate prediction of a daily maintenance dose of warfarin.
回顾性研究了47例患者的华法林抗凝数据，用于开发一种预测华法林每日维持剂量的算法。为47例患者中的每一位绘制了凝血酶原时间与累积华法林负荷剂量的关系图，并测量了从基线凝血酶原时间到20秒凝血酶原时间的曲线下面积（AREA）。通过回归分析得出华法林既定每日维持剂量与AREA之间的线性相关性：每日维持剂量（mg/天）=0.0465×（AREA）+1.5。然后利用该相关性预测了24例前瞻性研究患者的每日维持剂量。前瞻性研究中所有患者负荷后7天稳定期的平均凝血酶原时间为21.5±2.2秒，每位患者的7天平均凝血酶原时间在19至24秒之间。前瞻性研究结果表明，该技术可用于早期、准确地预测华法林的每日维持剂量。
