Ovesen L, Lyduch S, Ott P
Medical Department 3, Kommunehospitalet, Copenhagen, Denmark.
Eur J Clin Pharmacol. 1989;37(6):573-6. doi: 10.1007/BF00562547.
In a prospective, randomised trial the clinical utility of a predictive warfarin maintenance dosing technique was compared with the more commonly employed empirical dosing method. A preliminary study in 35 patients established the applied technique for predicting the maintenance dosage of warfarin from the prothrombin activity on Day 4 of initial standardised warfarin administration. Forty-three patients admitted with venous thrombotic disease were investigated. All received the same loading dose of warfarin (10 mg daily) until the prothrombin percentage activity (Normotest) was less than 25%. Significantly more patients were correctly stabilised when warfarin doses were based on prediction than when they were empirically adjusted (86% vs 50%). Also, the median number of days to achieve stable anticoagulation was lower (8 vs 11 days). It is concluded that this simple predictive technique to determine the maintenance dosage of warfarin is superior to empirical dosing.
在一项前瞻性随机试验中，将一种预测性华法林维持剂量技术的临床效用与更常用的经验性给药方法进行了比较。对35名患者的初步研究确定了从初始标准化华法林给药第4天的凝血酶原活性预测华法林维持剂量的应用技术。对43例因静脉血栓性疾病入院的患者进行了研究。所有患者均接受相同负荷剂量的华法林（每日10 mg），直至凝血酶原百分比活性（正常检测）低于25%。与经验性调整剂量相比，基于预测调整华法林剂量时，显著更多的患者得到了正确的稳定治疗（86%对50%）。此外，达到稳定抗凝的中位天数更低（8天对11天）。结论是，这种确定华法林维持剂量的简单预测技术优于经验性给药。
