关于痤疮发病机制的进一步观察

Further observations on the pathogenesis of acne.

作者信息

Cotterill J A, Cunliffe W J, Williamson B, Bulusu L

出版信息

Br Med J. 1972 Aug 19;3(5824):444-6. doi: 10.1136/bmj.3.5824.444.

DOI:10.1136/bmj.3.5824.444

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1786002/

Abstract

The composition of the lipid of the forehead skin surface and the sebum excretion rate were determined in 217 subjects and controls. Acne was associated with an increase in serum excretion rate and in the squalene and wax and sterol esters in surface lipid. The changes in sebum excretion rate and squalene were statistically significant only in women, but acne in men was associated with a significant decrease in the free fatty acid content or surface lipid.The increased amounts of squalene and wax esters may lead to pilosebaceous obstruction in acne subjects. The increased sebum excretion rate in acne may ensure increased production of sebaceous triglyceride substrate available for lipolysis to irritant free fatty acids, which may then mediate the inflammatory changes of acne.

摘要

对217名受试者及对照组测定了前额皮肤表面脂质的组成和皮脂排泄率。痤疮与血清排泄率以及表面脂质中角鲨烯、蜡和甾醇酯的增加有关。皮脂排泄率和角鲨烯的变化仅在女性中具有统计学意义，但男性痤疮与表面脂质中游离脂肪酸含量的显著降低有关。角鲨烯和蜡酯含量的增加可能导致痤疮患者毛囊皮脂腺阻塞。痤疮患者皮脂排泄率增加可能确保可用于脂解为刺激性游离脂肪酸的皮脂甘油三酯底物产量增加，而游离脂肪酸随后可能介导痤疮的炎症变化。

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