Cooper M F, McGrath H, Shuster S
Br J Dermatol. 1976 Feb;94(2):165-72. doi: 10.1111/j.1365-2133.1976.tb04366.x.
Lipogenesis from [14C] glucose was measured in skin biopsies from the shoulder-blade region of forty-two male subjects. In the acne age range, dermal lipogenesis showed an upward trend with increasing severity of acne; a similar trend was found in forehead sebum excretion rate, but no correlation was obvious between dermal lipogenesis (back) and sebum secretion rate (forehead) in the same subject. In older subjects, dermal lipogenesis was significantly increased in those with a past history of severe acne. At high rates of dermal lipogenesis there was a small but significant increase in wax ester labelling relative to triglyceride and squalene. No increase was found in squalene labelling relative to other lipids, either with increasing lipogenic rate or in severe acne. Dermal and epidermal lipogenesis rates showed no correlation with age. In dermis, however, there was a decrease in wax ester labelling relative to triglyceride, and a marked decrease in squalene labelling relative to both triglyceride and wax esters, with increasing age.
在42名男性受试者肩胛骨区域的皮肤活检样本中测定了由[14C]葡萄糖生成脂肪的过程。在痤疮发病年龄范围内，真皮脂肪生成随着痤疮严重程度的增加呈上升趋势；在前额皮脂分泌率方面也发现了类似趋势，但同一受试者的真皮脂肪生成（背部）与皮脂分泌率（前额）之间无明显相关性。在老年受试者中，有重度痤疮病史者的真皮脂肪生成显著增加。在真皮脂肪生成率较高时，相对于甘油三酯和角鲨烯，蜡酯标记有小幅但显著的增加。无论是脂肪生成率增加还是在重度痤疮患者中，相对于其他脂质，角鲨烯标记均未增加。真皮和表皮脂肪生成率与年龄无相关性。然而，在真皮中，相对于甘油三酯，蜡酯标记减少，相对于甘油三酯和蜡酯，角鲨烯标记显著减少，且随年龄增长而变化。
