Di Perri T, Forconi S, Guerrini M, Pasini F L, Del Cippola R, Rossi C, Angnusdei D
Angiology. 1979 Jan;30(1):13-20. doi: 10.1177/000331977903000102.
Cinnarizine, a drug capable of improving blood flow, was studied for its action on blood viscosity and its main components in patients affected by peripheral obliterative arterial diseases (POAD). Both acute and chronic administration of the drug diminished the increased whole-blood viscosity in patients, without affecting plasma and serum viscosity, hematocrit, plasma fibrinogen concentration, and plasma osmolality. Since cinnarizine also led to a significant increase of peripheral muscular blood flow, it was hypothesized that this action may be due to an increased deformability of the red cells, and may play a considerable role in the therapeutic approach to POAD.
桂利嗪是一种能够改善血流的药物，本研究观察了其对周围性闭塞性动脉疾病（POAD）患者血液粘度及其主要成分的作用。急性和慢性给予该药物均能降低患者全血粘度的升高，而不影响血浆和血清粘度、血细胞比容、血浆纤维蛋白原浓度及血浆渗透压。由于桂利嗪还能显著增加外周肌肉血流量，因此推测该作用可能是由于红细胞变形性增加所致，并且在POAD的治疗方法中可能发挥重要作用。
