Bareford D, Lucas G S, Caldwell N M, Stone P C, Baar S, Stuart J
J Clin Pathol. 1985 Feb;38(2):135-9. doi: 10.1136/jcp.38.2.135.
A rheological study of 32 patients with peripheral occlusive arterial disease (POAD), compared with 32 matched healthy controls, has shown no loss of erythrocyte deformability as measured by filtration methods (using initial flow rate and positive pressure instruments, polycarbonate and silver membranes, and 3 microns and 5 microns diameter pores) or by viscometry (using laser visco-diffractometric and high shear rate viscosity methods). Erythrocyte ATP concentration in POAD was also normal. Patients with POAD showed a small (4 fl) increase in mean erythrocyte volume, associated with a raised serum gamma-glutamyl transpeptidase concentration, which correlated with erythrocyte filtration and viscometric measurements. Previous reports of impaired blood filterability in POAD probably reflect the effects of accompanying leucocytosis, plasma hyperfibrinogenaemia, or an increase in erythrocyte size, but not an intrinsic loss of erythrocyte deformability.
一项针对32例外周闭塞性动脉疾病（POAD）患者的流变学研究，与32例匹配的健康对照者相比，结果显示，通过过滤方法（使用初始流速和正压仪器、聚碳酸酯和银膜以及直径为3微米和5微米的孔）或粘度测定法（使用激光粘度衍射法和高剪切速率粘度法）测量，红细胞变形性没有损失。POAD患者的红细胞ATP浓度也正常。POAD患者的平均红细胞体积有小幅（4飞升）增加，与血清γ-谷氨酰转肽酶浓度升高有关，该浓度与红细胞过滤和粘度测量相关。先前关于POAD患者血液过滤性受损的报道可能反映了伴随的白细胞增多、血浆高纤维蛋白原血症或红细胞大小增加的影响，而非红细胞变形性的内在损失。
