年龄和睾酮对雄性大鼠对对氯苯丙氨酸反应的影响。

Influence of age and of testosterone on the response of male rats to parachlorophenylalanine.

Bond V J, Shillito E E, Vogt M

Br J Pharmacol. 1972 Sep;46(1):46-55. doi: 10.1111/j.1476-5381.1972.tb06847.x.

Abstract

Castrated male rats and male rats that had been castrated as well as adrenalectomized, showed hypersexual behaviour 24 h after treatment with parachlorophenylalanine (PCPA), as did intact rats.2. A dose of PCPA 100 mg/kg was sufficient to induce mounting behaviour; this dose lowered the cerebral 5-hydroxytryptamine (5-HT) to about 50% in 24 h and further to 40% in 72 hours.3. Groups of juvenile male rats treated chronically with PCPA 100 mg/kg or 50 mg/kg, or with testosterone propionate 1.25 mg, showed hair loss after three weeks of treatment (6 injections), because of increased social interaction.4. Groups of intact male rats 9-11 weeks old given testosterone propionate 1.25 mg subcutaneously, showed mounting behaviour 3-5 h after the injection which was indistinguishable from the behaviour seen 24 h after treatment with PCPA 100 mg/kg. The 5-HT content of the brain was not altered by testosterone.5. The number of rats which showed mounting after PCPA treatment did not change with age, but the younger rats made more mounts in the observation time than rats more than three months old.6. The age of castration (3 weeks or 4 months) did not influence the results.

摘要

阉割的雄性大鼠以及既被阉割又切除肾上腺的雄性大鼠，在用对氯苯丙氨酸（PCPA）治疗24小时后表现出性欲亢进行为，完整的大鼠也是如此。
100毫克/千克的PCPA剂量足以诱发爬跨行为；该剂量在24小时内将大脑5-羟色胺（5-HT）降至约50%，并在72小时内进一步降至40%。
用100毫克/千克或50毫克/千克的PCPA或1.25毫克丙酸睾酮长期治疗的幼年雄性大鼠组，在治疗三周（6次注射）后由于社交互动增加而出现脱发。
皮下注射1.25毫克丙酸睾酮的9-11周龄完整雄性大鼠组，在注射后3-5小时表现出爬跨行为，这与用100毫克/千克PCPA治疗24小时后观察到的行为无法区分。大脑的5-HT含量不受睾酮影响。
PCPA治疗后表现出爬跨行为的大鼠数量不随年龄变化，但在观察期内，较年轻的大鼠比三个月以上的大鼠有更多的爬跨行为。
阉割的年龄（3周或4个月）不影响结果。