Melamed E, Larsen B
Ann Neurol. 1979 Jan;5(1):79-88. doi: 10.1002/ana.410050112.
Regional cerebral blood flow (rCBF) was measured in human subjects during saccadic eye movements by a 254-channel dynamic gamma camera. Focal rCBF increases were repeatedly observed in an area within the middle precentral and premotor regions which corresponds to the frontal eye field in humans. Our findings suggest that this region is localized between the "face" and "hand" areas in the precentral gyrus and extends anteriorly out of the primary motor strip into the adjacent premotor zone. In addition, saccades were associated with focal blood flow increases in regions corresponding to the frontal supplementary motor area and to the posterior temporooccipital visual association cortex. Similar changes in patterns of rCBF occurred during contralateral and ipsilateral horizontal saccades and also during vertical saccades, and did not differ between the right and left hemispheres. Focal rCBF increases were observed in the frontal eye field during several additional test procedures including ocular fixation and visual perception of a nonmoving target, auditory stimulation with closed eyes, and reading. It is presumed that these focal flow increases reflect increased localized neuronal activity and metabolic rate and therefore permit visualization of the cortical activation pattern associated with saccadic eye movements in humans.
利用一台254通道动态伽马相机，在人类受试者进行眼球扫视运动期间测量了局部脑血流量（rCBF）。在中央前回中部和运动前区的一个区域内反复观察到局部rCBF增加，该区域对应于人类的额叶眼区。我们的研究结果表明，该区域位于中央前回的“面部”和“手部”区域之间，并向前延伸出初级运动区，进入相邻的运动前区。此外，扫视运动与额叶辅助运动区以及颞枕后视觉联合皮层区域的局部血流增加有关。在对侧和同侧水平扫视运动以及垂直扫视运动期间，rCBF模式出现了类似变化，并且左右半球之间没有差异。在包括注视、对静止目标的视觉感知、闭眼听觉刺激和阅读在内的几种额外测试过程中，额叶眼区均观察到局部rCBF增加。据推测，这些局部血流增加反映了局部神经元活动和代谢率的增加，因此能够显示与人类眼球扫视运动相关的皮质激活模式。
