Darby D G, Nobre A C, Thangaraj V, Edelman R, Mesulam M M, Warach S
Department of Neurology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
Neuroimage. 1996 Feb;3(1):53-62. doi: 10.1006/nimg.1996.0006.
The location of the human cortical substrate underlying simple horizontal saccadic eye movements was investigated using echoplanar functional magnetic resonance imaging (fMRI) in young healthy volunteers. Echoplanar imaging with signal targeting and alternating radiofrequency (EPISTAR), a novel perfusion technique, measured signal intensity changes in one to four contiguous 10-mm slices centered to include both striate cortex and putative frontal eye fields during horizontal saccade and fixation conditions. Subtraction images of self-paced visually guided saccadic versus fixation conditions showed bilateral marked and statistically significant localized signal increases in the precentral region (Brodmann areas 4, 6) and peristriate cortex (areas 17, 18, 19) and qualitative increases in the superior medial frontal region, as identified by a Talairach-Tournoux generalized template in the brain slices that were scanned. Additional parietal activation occurred during a target-guided saccade task. Our data (i) support the localization of the human FEF, as identified by simple, nonexploratory saccadic eye movements, in the precentral motor strip and premotor cortex, (ii) show individual variability in the exact anatomical location of saccade-related activations, and (iii) confirm that the EPISTAR technique can demonstrate localized signal increases during a behavioral task.
利用回波平面功能磁共振成像（fMRI）技术，在年轻健康志愿者中研究了简单水平眼球扫视运动背后的人类皮质基质的位置。一种新型灌注技术——带信号靶向和交替射频的回波平面成像（EPISTAR），测量了在水平扫视和注视条件下，以包括纹状皮质和假定的额叶眼区为中心的一到四个连续10毫米切片中的信号强度变化。自我控制的视觉引导扫视与注视条件下的相减图像显示，在中央前区（布罗德曼第4、6区）和纹周皮质（17、18、19区）出现双侧明显且具有统计学意义的局部信号增加，以及在扫描的脑切片中通过Talairach - Tournoux通用模板确定的额上内侧区的定性增加。在目标引导扫视任务期间还出现了额外的顶叶激活。我们的数据（i）支持通过简单的非探索性眼球扫视运动确定的人类额叶眼区（FEF）位于中央前运动带和运动前皮质，（ii）显示了扫视相关激活的确切解剖位置存在个体差异，并且（iii）证实EPISTAR技术可以在行为任务期间显示局部信号增加。
