Structue-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. I. Dissociation rate constants of various enzyme-cardiac glycoside complexes formed in the presence of magnesium and phosphate.

Suppr

超能文献

作者信息

Yoda A

出版信息

Mol Pharmacol. 1973 Jan;9(1):51-60.

PMID:4265446

Abstract

摘要

相似文献

Structue-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. I. Dissociation rate constants of various enzyme-cardiac glycoside complexes formed in the presence of magnesium and phosphate.

Mol Pharmacol. 1973 Jan;9(1):51-60.

Structure-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. 3. Dissociation rate constants of various enzyme-cardiac glycoside complexes formed in the presence of sodium, magnesium, and adenosine triphosphate.强心甾类化合物抑制钠钾依赖型三磷酸腺苷酶的构效关系。3. 在钠、镁和三磷酸腺苷存在下形成的各种酶 - 强心苷复合物的解离速率常数。

Mol Pharmacol. 1974 May;10(3):494-500.

Structure-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. II. Association rate constants of various enzyme-cardiac glycoside complexes.强心甾体类化合物对钠钾依赖型三磷酸腺苷酶抑制作用的构效关系。II. 各种酶-强心苷复合物的缔合速率常数。

Mol Pharmacol. 1973 Nov;9(6):766-73.

Structure-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. IV. Dissociation rate constants for complexes of the enzyme with cardiac oligodigitoxides.

Mol Pharmacol. 1975 Sep;11(5):647-52.

Association and dissociation rate constants of the complexes between various cardiac aglycones and sodium- and potassium-dependent adenosine triphosphatase formed in the presence of magnesium and phosphate.

Mol Pharmacol. 1977 Mar;13(2):352-61.

Reversibility of the interaction of strophanthidin bromoacetate with the cardiotonic steroid binding site of sodium- and potassium-dependent adenosine triphosphatase.

Mol Pharmacol. 1973 Sep;9(5):676-85.

The titration of the cardiac glycoside binding site of the (Na+ + K+)-adenosine triphosphatase.（钠钾）-三磷酸腺苷酶的强心苷结合位点的滴定

J Biol Chem. 1972 Dec 10;247(23):7634-41.

Dissociation of the positive inotropic action of digitalis from inhibition of sodium- and potassium-activated adenosine triphosphate.洋地黄正性肌力作用与钠钾激活三磷酸腺苷抑制作用的解离。

J Pharmacol Exp Ther. 1973 Apr;185(1):1-11.

The role of phospholipids in the binding of ouabain to sodium- and potassium-dependent adenosine triphosphatase.

Mol Pharmacol. 1973 May;9(3):350-9.

On the reversibility of binding of cardiotonic steroids to a partially purified (Na+K)-activated adenosinetriphosphatase from beef brain.

Biochem Biophys Res Commun. 1970 Aug 24;40(4):880-6. doi: 10.1016/0006-291x(70)90985-x.

引用本文的文献

Molecular Basis of Na, K-ATPase Regulation of Diseases: Hormone and FXYD2 Interactions.钠钾ATP酶疾病调节的分子基础：激素与FXYD2的相互作用

Int J Mol Sci. 2024 Dec 13;25(24):13398. doi: 10.3390/ijms252413398.

The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na pump endocrine system.泵、交换器和圣灵：关于哇巴因-Na 泵内分泌系统的起源和 40 年的发展思路。

Am J Physiol Cell Physiol. 2018 Jan 1;314(1):C3-C26. doi: 10.1152/ajpcell.00196.2017. Epub 2017 Nov 7.

Digoxin derivatives with enhanced selectivity for the α2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits.具有增强的 α2 同工型 Na,K-ATPase 选择性的地高辛衍生物：对兔眼内压的影响。

J Biol Chem. 2014 Jul 25;289(30):21153-62. doi: 10.1074/jbc.M114.557629. Epub 2014 Jun 10.

Ouabain-digoxin antagonism in rat arteries and neurones.哇巴因与地高辛在大鼠动脉和神经元中的拮抗作用。

J Physiol. 2014 Mar 1;592(5):941-69. doi: 10.1113/jphysiol.2013.266866. Epub 2013 Dec 16.

A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase.强心甾体糖部分和甾体羟基与 Na,K-ATP 酶结合的功能重要性的结构观点。

J Biol Chem. 2013 Mar 1;288(9):6602-16. doi: 10.1074/jbc.M112.442137. Epub 2013 Jan 22.

Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.α-D-/α-L-鼠李糖基和阿米西托糖基洋地黄毒苷元低聚物作为抗肿瘤药物的合成与评价

ACS Med Chem Lett. 2011 Apr 14;2(4):264-269. doi: 10.1021/ml100290d.

Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.洋地黄毒苷单糖的立体化学研究：具有增强凋亡活性和对人非小细胞肺癌细胞生长抑制作用的新型抗癌类似物。

ACS Med Chem Lett. 2011 Jan 13;2(1):73-78. doi: 10.1021/ml100219d.

C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.C5'-烷基取代对洋地黄毒苷元α-L-糖苷癌症细胞毒性的影响。

ACS Med Chem Lett. 2011 Apr 14;2(4):259-263. doi: 10.1021/ml100291n.

Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase.洋地黄类糖苷对人 Na,K-ATPase 同工型的选择性。

J Biol Chem. 2010 Jun 18;285(25):19582-92. doi: 10.1074/jbc.M110.119248. Epub 2010 Apr 13.

The influence of reduced serum potassium level on the toxicity of some cardenolides in guinea pigs.血清钾水平降低对豚鼠某些强心苷毒性的影响。

Basic Res Cardiol. 1981 Jan-Feb;76(1):62-78. doi: 10.1007/BF01908163.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验