Fernelius A L, Amtower W C, Lambert G, McClurkin A W, Matthews P J
Can J Comp Med. 1973 Jan;37(1):13-20.
A noncytopathogenic field strain of bovine viral diarrhea virus (BVDV) was isolated from an Iowa farm brood sow and from her hysterectomy-derived, colostrum-deprived (HDCD) piglets. This field isolant was fully virulent for a neonatal calf. The NADL strain of BVDV was passaged through a series of HDCD piglets with no resultant loss of virulence for neonatal calves. Most of the BVD viral isolants recovered from pigs had been changed from a cytopathogenic biotype to a noncytopathogenic biotype. Circumstantial evidence points to swine as "carrier" hosts of BVDV.
从爱荷华州一个农场的母猪及其子宫切除后初乳缺乏(HDCD)的仔猪中分离出一种牛病毒性腹泻病毒(BVDV)的非细胞病变野毒株。该野毒株对新生小牛具有完全的致病性。BVDV的NADL毒株通过一系列HDCD仔猪传代,对新生小牛的毒力没有因此而丧失。从猪身上分离出的大多数BVD病毒株已从细胞病变生物型转变为非细胞病变生物型。间接证据表明猪是BVDV的“携带者”宿主。