单价阴离子对肾上腺髓质储存囊泡中儿茶酚胺通量和三磷酸腺苷酶活性的影响。
The effects of univalent anions on catecholamine fluxes and adenosine triphosphatase activity in storage vesicles from the adrenal medulla.
作者信息
Taugner G
出版信息
Biochem J. 1972 Dec;130(4):969-73. doi: 10.1042/bj1300969.
Abstract
- Influx and efflux of catecholamine and adenosine triphosphatase activity were studied in storage vesicles of bovine adrenal medulla. 2. In the absence of ATP the influx of catecholamine was slow and was not influenced by various anions, whereas the efflux increased in the sequence of anions given by the lyotrophic series. 3. In the presence of ATP the efflux was enhanced compared with that in the absence of ATP; the anion-dependent sequence, however, in which the efflux increased was the same as in the absence of ATP. 4. The ATP-dependent catecholamine influx and the adenosine triphosphatase activity are correlated. The sequence in which anions affect adenosine triphosphatase activity and catecholamine influx, however, is completely different from the lyotrophic anion series. 5. No correlation was found between adenosine triphosphatase activity and the efflux of catecholamine.
摘要
- 对牛肾上腺髓质储存囊泡中儿茶酚胺的流入和流出以及三磷酸腺苷酶活性进行了研究。2. 在没有ATP的情况下，儿茶酚胺的流入缓慢，且不受各种阴离子的影响，而流出则按照离子亲和序列中给出的阴离子顺序增加。3. 在有ATP的情况下，与没有ATP时相比，流出增强；然而，流出增加的阴离子依赖性序列与没有ATP时相同。4. 依赖ATP的儿茶酚胺流入与三磷酸腺苷酶活性相关。然而，阴离子影响三磷酸腺苷酶活性和儿茶酚胺流入的序列与离子亲和阴离子序列完全不同。5. 未发现三磷酸腺苷酶活性与儿茶酚胺流出之间存在相关性。
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本文引用的文献
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Uptake of catecholamines by a particulate fraction of the adrenal medulla.肾上腺髓质微粒体部分对儿茶酚胺的摄取
J Biol Chem. 1962 Jul;237:2311-7.
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Influence of chloride ions and ATP-Mg++ on the release of catecholamines from isolated adrenal medullary granules.
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Release of catecholamines from isolated adrenal chromaffin granules by endogenous ATP.内源性ATP促使分离的肾上腺嗜铬颗粒释放儿茶酚胺。
Mol Pharmacol. 1968 Mar;4(2):196-9.
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Phosphorylation of membrane components of adrenal chromaffin granules by adenosine triphosphate.三磷酸腺苷对肾上腺嗜铬粒细胞膜成分的磷酸化作用。
Mol Pharmacol. 1971 Jan;7(1):52-65.
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[ATP as catecholamine-liberator in isotonic salt solutions?].[三磷酸腺苷在等渗盐溶液中作为儿茶酚胺释放剂？]
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Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966;255(3):266-86.
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