Faustov L A
Arkh Patol. 1979;41(3):25-9.
Morphological and histochemical examinations of the adrenal cortex of 150 rats with intestinal carcinogenesis caused by 1,2-dimethylhydrasine, and comparison of the results with control results in 20 intact rats showed the latent period to occur against the background of atrophic changes in the cortical matter consisting in a decrease in the adrenal weight, narrowing of the cortical matter, decreasing diameter of the secretory cells nuclei, accumulation of lipids and cholesterol in zona fasciculata and zona reticulosa, and decreased content of ascorbic acid. In contrast, the period of tumour growth within the intestinal mucosa coincides with hypertrophic changes in the adrenal cortex. In extensive cancer, the intensity of these hypertrophic changes increased, and dystrophically changed cells and micronecroses appeared.
对150只由1,2 - 二甲基肼诱发肠道癌变的大鼠的肾上腺皮质进行形态学和组织化学检查，并将结果与20只正常大鼠的对照结果进行比较，结果显示潜伏期出现在皮质物质萎缩性变化的背景下，表现为肾上腺重量减轻、皮质物质变窄、分泌细胞核直径减小、束状带和网状带中脂质和胆固醇积聚以及抗坏血酸含量降低。相反，肠道黏膜内肿瘤生长阶段与肾上腺皮质的肥大性变化同时出现。在广泛的癌症中，这些肥大性变化的强度增加，出现了营养不良性改变的细胞和微坏死。
