Faustov L A
Biull Eksp Biol Med. 1979 Jul;88(7):78-81.
Pathomorphology of the neurosecretory hypothalamo-hypophyseal system and the thyroid gland of 150 rats of both sexes was investigated in intestinal carcinogenesis induced by 1.2-dimethyl hydrazine. Inhibition of the neurosecretory activity of paraventricular and supraoptical nuclei as well as atrophic changes in th: thyroid gland were found to be associated with the latent period of carcinogenesis. The arising of the intestinal tumor is accompanied by hypertrophy of neurons and their nuclei, by a decrease in the neurosecretory substance content and the thyroid gland tendency to return to normal. The tumor spreading provoked neuron hypertrophy and the reduction of the neurosecretory substance as well and pronounced atrophic changes in the thyroid gland.
在由1,2 - 二甲基肼诱导的肠道癌发生过程中，对150只雌雄大鼠的神经分泌下丘脑 - 垂体系统和甲状腺的病理形态学进行了研究。发现室旁核和视上核神经分泌活动的抑制以及甲状腺的萎缩性变化与癌发生的潜伏期有关。肠道肿瘤的出现伴随着神经元及其细胞核的肥大、神经分泌物质含量的减少以及甲状腺恢复正常的趋势。肿瘤扩散也引发了神经元肥大和神经分泌物质的减少以及甲状腺明显的萎缩性变化。
