Faustov L A
Arkh Patol. 1983;45(9):35-41.
Pathomorphology of endocrine glands in 62 rats in the latent period of intestinal carcinogenesis caused by 1,2-dimethyl hydrazine was studied. The morphological picture of the latent period includes atrophic changes of the adrenal cortex and the thyroid gland, A- and B-cells of pancreatic insulae and interstitial Leidig cells, as well as severer dystrophic changes of thyreotrophs, thymus epithelium, spermatogenic epithelium, and granuloses of growing follicles. These changes are combined with hypertrophy of follicle-stimulating gonadotrophs, hyperplasia of the body-tissue in the ovaries, as well as accumulation of neurosecretory substance in neurons of paraventricular and supraoptic nuclei of hypothalamus, neurosecretory pathways, and neurohypophysis. No morphological changes were found in the latent period in hypophysis acidophilic cells, lymphoid elements of the thymus, primordial follicles and cells of parathyroid glands.
研究了1,2 - 二甲基肼诱发肠道癌潜伏期62只大鼠内分泌腺的病理形态学。潜伏期的形态学表现包括肾上腺皮质和甲状腺、胰岛的A细胞和B细胞以及间质莱迪希细胞萎缩性变化，还有促甲状腺激素细胞、胸腺上皮、生精上皮和生长卵泡颗粒细胞更严重的营养不良性变化。这些变化伴有促卵泡性腺激素细胞肥大、卵巢体组织增生，以及下丘脑室旁核和视上核神经元、神经分泌途径和神经垂体中神经分泌物质的积累。垂体嗜酸性细胞、胸腺淋巴样成分、原始卵泡和甲状旁腺细胞在潜伏期未发现形态学变化。
