Greenfield J C, Harley A, Thompson H K, Wallace A G
J Clin Invest. 1968 Oct;47(10):2411-21. doi: 10.1172/JCI105924.
In 13 patients who had atrial fibrillation the ascending aortic pressure-flow relationships were measured by the pressure gradient technique. Both the pressure and flow curves were similar in contour to ones previously obtained by this method. From these recordings, relationships between the phases of systole, the ventricular filling time, and various derived parameters of pressure and flow such as the pulse pressure, stroke volume, peak flow, stroke work, and peak power were evaluated. For stroke volumes greater than 15 cm(3) there was little change in the duration of systole in an individual patient. In each patient both the preejection period and the duration of ejection showed a good correlation with stroke volume, peak flow, stroke work, and peak power. When data from all patients were examined, the relationship between stroke volume and duration of ejection was found to be curvilinear and had an overall correlation of r=0.91. There was marked variation from patient to patient in duration of both the preejection period and systole. Similar correlations between the phases of systole were noted with peak flow, peak power, and stroke work. A positive but mediocre correlation was found between the previous RR interval (an index of ventricular filling time) and the subsequent stroke volume. The correlation, in six patients, between two previous RR intervals and stroke volume was considerably better. The relationship between the pulse pressure and stroke volume was reasonably close except in one patient; however, the group correlation was poor due to differences between individuals.
在13例心房颤动患者中，采用压力梯度技术测量升主动脉压力-流量关系。压力和流量曲线的轮廓与此前用该方法获得的曲线相似。根据这些记录，评估了收缩期各阶段、心室充盈时间以及压力和流量的各种派生参数（如脉压、每搏量、峰值流量、每搏功和峰值功率）之间的关系。对于每搏量大于15立方厘米的患者，个体患者的收缩期持续时间变化不大。在每位患者中，射血前期和射血持续时间与每搏量、峰值流量、每搏功和峰值功率均呈现良好的相关性。当检查所有患者的数据时，发现每搏量与射血持续时间之间的关系呈曲线关系，总体相关性为r = 0.91。射血前期和收缩期的持续时间在患者之间存在显著差异。收缩期各阶段与峰值流量、峰值功率和每搏功之间也存在类似的相关性。在前一个RR间期（心室充盈时间的指标）与随后的每搏量之间发现了正相关但中等程度的相关性。在6例患者中，两个前RR间期与每搏量之间的相关性明显更好。除1例患者外，脉压与每搏量之间的关系相当密切；然而，由于个体差异，组内相关性较差。
