单次口服阿司匹林对血小板花生四烯酸聚集反应的影响。
Effect of a single oral dose of aspirin on the platelet aggregation response to arachidonic acid.
作者信息
Bye A, Lewis Y, O'Grady J
出版信息
Br J Clin Pharmacol. 1979 Mar;7(3):283-6. doi: 10.1111/j.1365-2125.1979.tb00933.x.
Abstract
1 The platelet aggregation response to arachidonic acid ex vivo was measured in six volunteers daily before and for 10 days after a single oral dose of 600 mg aspirin. 2 Arachidonic acid induced aggregation of platelets from all subjects before aspirin and aggregation occurred after an interval which varied inversely with the concentration of arachidonic acid. No aggregation occurred for 4 days after aspirin; a reduced response, compared with pre-aspirin values, was obtained on the 5th, 6th and 8th day. The values on days 7, 9 and 10 were not consistently different from the pre-aspirin values. In 6 subjects 24 h after aspirin ingestion the addition of 10--25% v/v normal platelets restored the aggregation response. 3 It is concluded that aspirin has an effect on the platelet precursors in the marrow in addition to its effect on circulating platelets.
摘要
- 在六名志愿者中，每天在单次口服600毫克阿司匹林之前以及之后10天测量对花生四烯酸的体外血小板聚集反应。2. 花生四烯酸在服用阿司匹林前可诱导所有受试者的血小板聚集，且聚集在与花生四烯酸浓度呈反比的间隔时间后发生。服用阿司匹林后4天未发生聚集；在第5、6和8天获得了与服用阿司匹林前值相比降低的反应。第7、9和10天的值与服用阿司匹林前的值没有持续差异。在6名受试者中，服用阿司匹林24小时后添加10% - 25%（体积/体积）的正常血小板可恢复聚集反应。3. 得出结论，阿司匹林除了对循环血小板有作用外，还对骨髓中的血小板前体有作用。
相似文献
1
Effect of a single oral dose of aspirin on the platelet aggregation response to arachidonic acid.单次口服阿司匹林对血小板花生四烯酸聚集反应的影响。
Br J Clin Pharmacol. 1979 Mar;7(3):283-6. doi: 10.1111/j.1365-2125.1979.tb00933.x.
2
The effect of arachidonic acid on the aggregability of human platelet rich plasma.花生四烯酸对人富血小板血浆聚集性的影响。
Prostaglandins Leukot Med. 1982 Feb;8(2):133-9. doi: 10.1016/s0262-1746(82)80005-x.
3
Relative effects of aspirin on platelet aggregation and prostaglandin-mediated coronary vasodilatation in the dog.
Circulation. 1980 Dec;62(6):1221-7. doi: 10.1161/01.cir.62.6.1221.
4
The effect of low-dose aspirin and platelet aggregation in familial hypercholesterolaemia.小剂量阿司匹林对家族性高胆固醇血症患者血小板聚集的影响
S Afr Med J. 1983 Jul 9;64(2):49-52.
5
Prostaglandin E2 potentiation of platelet aggregation induced by LASS endoperoxide: absent in storage pool disease, normal after aspirin ingestion.LASS内过氧化物诱导的血小板聚集的前列腺素E2增强作用：在储存池病中不存在，阿司匹林摄入后正常。
Br J Haematol. 1976 Feb;32(2):257-72. doi: 10.1111/j.1365-2141.1976.tb00929.x.
6
Effects of aspirin and propranolol on feline platelet aggregation.阿司匹林和普萘洛尔对猫血小板聚集的影响。
Am J Vet Res. 1985 Sep;46(9):1820-3.
7
Rapid return of cyclo-oxygenase active platelets in dogs after a single oral dose of aspirin.
Prostaglandins. 1981 Nov;22(5):761-72. doi: 10.1016/0090-6980(81)90215-x.
8
Failure of superoxide dismutase to alter equine arachidonic acid-induced platelet aggregation, in vitro or ex vivo.
Am J Vet Res. 1985 May;46(5):1104-6.
9
Effects of 6-[p-(4-phenylacetylpiperazin-1-yl)phenyl]-4,5-dihydro-3(2H)pyridazinone (CCI 17810) and aspirin on platelet aggregation and adhesiveness.6-[对-(4-苯乙酰基哌嗪-1-基)苯基]-4,5-二氢-3(2H)哒嗪酮（CCI 17810）和阿司匹林对血小板聚集及黏附性的影响
Br J Pharmacol. 1981 Apr;72(4):697-705. doi: 10.1111/j.1476-5381.1981.tb09151.x.
10
[Effects of low-dose acetylsalicylic acid on thrombocytes in health subjects and in patients with coronary heart disease].
Dtsch Med Wochenschr. 1989 Aug 18;114(33):1231-6. doi: 10.1055/s-2008-1066746.
引用本文的文献
1
Safety and effectiveness of low dosing of double antiplatelet therapy during long-term left ventricular support with the INCOR system.
J Artif Organs. 2010 Dec;13(4):202-6. doi: 10.1007/s10047-010-0527-7. Epub 2010 Dec 4.
2
Possible mechanisms of aspirin resistance.阿司匹林抵抗的可能机制。
J Thromb Thrombolysis. 2002 Feb;13(1):49-56. doi: 10.1023/a:1015324310374.
3
Aspirin in cardiovascular disease.阿司匹林在心血管疾病中的应用
Drugs. 1988 Feb;35(2):154-76. doi: 10.2165/00003495-198835020-00005.
4
The effects of varying doses of aspirin on human platelet activation induced by PAF, collagen and arachidonic acid.不同剂量阿司匹林对由血小板活化因子、胶原蛋白和花生四烯酸诱导的人体血小板活化的影响。
Br J Clin Pharmacol. 1992 Jan;33(1):25-31. doi: 10.1111/j.1365-2125.1992.tb03996.x.
本文引用的文献
1
Platelet protein synthesis studied in a cell-free system.在无细胞体系中研究血小板蛋白质合成。
Experientia. 1970;26(7):786-9. doi: 10.1007/BF02232552.
2
A method for demonstrating shortened platelet survival utilizing recovery from aspirin effect.一种利用阿司匹林效应恢复来证明血小板存活时间缩短的方法。
J Pediatr. 1974 Mar;84(3):350-4. doi: 10.1016/s0022-3476(74)80715-8.
3
Effects of salicylates on human platelets.
Lancet. 1968 Apr 13;1(7546):779-83. doi: 10.1016/s0140-6736(68)92228-9.
4
A simple nonradioisotope technic for the determination of platelet life-span.
N Engl J Med. 1975 Jun 19;292(25):1310-3. doi: 10.1056/NEJM197506192922502.
5
The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.阿司匹林对人体血小板作用的机制。I. 微粒体部分蛋白质的乙酰化作用。
J Clin Invest. 1975 Sep;56(3):624-32. doi: 10.1172/JCI108132.
6
Effect of aspirin on prostaglandin synthesis by human platelets.阿司匹林对人血小板前列腺素合成的影响。
Prostaglandins. 1976 Nov;12(5):829-35. doi: 10.1016/0090-6980(76)90056-3.
7
Acetylation of prostaglandin synthase by aspirin.阿司匹林对前列腺素合酶的乙酰化作用。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3073-6. doi: 10.1073/pnas.72.8.3073.
Zotero 插件