遗传性血管性水肿：用达那唑治疗。病例报告。
Hereditary angio-oedema: treatment with danazol. Report of a case.
作者信息
Tappeiner G, Hintner H, Glatzl J, Wolff K
出版信息
Br J Dermatol. 1979 Feb;100(2):207-12. doi: 10.1111/j.1365-2133.1979.tb05562.x.
An 8-year-old boy with hereditary angio-oedema was treated with danazol under close endocrinological supervision. The boy's C1 esterase inhibitor (C1inh) and C4 levels increased rapidly to near normal values under a daily dose of 400 mg and were maintained at about 50% of the normal by maintenance doses of 200 mg danazol every other day. Throughout the entire treatment period (11 months) the boy has been maintained free from attacks of angio-oedema. No hormonal imbalance was detected in the follow-up period. Our results indicate that danazol should be suitable for the treatment of HAE not only in adults but also in prepubescent children.
一名患有遗传性血管性水肿的8岁男孩在密切的内分泌学监测下接受了达那唑治疗。在每日400毫克的剂量下，男孩的C1酯酶抑制剂（C1inh）和C4水平迅速升至接近正常水平，并通过每隔一天服用200毫克达那唑的维持剂量维持在正常水平的约50%。在整个治疗期间（11个月），该男孩一直未出现血管性水肿发作。随访期间未检测到激素失衡。我们的结果表明，达那唑不仅适用于成人遗传性血管性水肿的治疗，也适用于青春期前儿童。
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