Wüthrich B, Grob P J
Dermatologica. 1980;160(3):167-74.
A mother and her son are described who both suffer from hereditary angiooedema. Both were treated with Danazol, a synthetic derivative of ethisterone. The prophylactic clinical effect seemed obvious, and also the serum concentration of the complement component C4, which had regularly been lower before treatment, became normal. However, no change of the serum concentration of the C1 esterase inhibitor could be demonstrated; this is in contrast to observations of other authors.
本文描述了一位患有遗传性血管性水肿的母亲及其儿子。两人均接受了达那唑治疗，达那唑是炔孕酮的合成衍生物。预防性临床效果似乎很明显，而且治疗前一直偏低的补体成分C4的血清浓度也恢复正常。然而，未发现C1酯酶抑制剂的血清浓度有变化；这与其他作者的观察结果相反。
