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Comparative inhibition of thrombin, plasmin, trypsin, and complement by benzamidines using substituent constants and regression analysis.

作者信息

Coats E A

出版信息

J Med Chem. 1973 Oct;16(10):1102-6. doi: 10.1021/jm00268a008.

DOI:10.1021/jm00268a008
PMID:4270699
Abstract
摘要

相似文献

1
Comparative inhibition of thrombin, plasmin, trypsin, and complement by benzamidines using substituent constants and regression analysis.
J Med Chem. 1973 Oct;16(10):1102-6. doi: 10.1021/jm00268a008.
2
Inhibition of four human serine proteases by substituted benzamidines.
J Med Chem. 1978 Dec;21(12):1202-7. doi: 10.1021/jm00210a006.
3
A comprehensive study on the mechanism of inhibition of serine proteases by benzamidines based on quantitative structure-activity relationship studies.基于定量构效关系研究的苯甲脒对丝氨酸蛋白酶抑制机制的综合研究。
Arzneimittelforschung. 1987 Jan;37(1):47-50.
4
[Inhibition of thrombin, plasmin and trypsin effect by alkyl- and alkoxybenzamidine].[烷基和烷氧基苯甲脒对凝血酶、纤溶酶和胰蛋白酶作用的抑制]
Pharmazie. 1970 Sep;25(9):551-4.
5
[Free-Wilson analysis of the inhibitory effect of 4-substituted benzamidines on thrombin, plasmin and trypsin (author's transl)].4-取代苯甲脒对凝血酶、纤溶酶和胰蛋白酶抑制作用的自由威尔逊分析(作者译)
Pharmazie. 1979;34(9):554-6.
6
[Synthetic inhibitors of serine proteinases. 12. The inhibition of trypsin, plasmin and thrombin by 3-[amidinophenyl]-1-phenyl-propanone-(1) with substituents in the aliphatic intermediate chain].[丝氨酸蛋白酶的合成抑制剂。12. 具有脂肪族中间链取代基的3-[脒基苯基]-1-苯基-丙酮-(1)对胰蛋白酶、纤溶酶和凝血酶的抑制作用]
Pharmazie. 1976 Jun;31(6):410-1.
7
[Hansch analysis of the inhibitory action of 3- and 4-substituted benzamidines on thrombin, plasmin and trypsin (author's transl)].3-和4-取代苯甲脒对凝血酶、纤溶酶和胰蛋白酶抑制作用的汉斯ch分析(作者译)
Pharmazie. 1979 Oct;34(10):649-53.
8
[Synthetic inhibitors of serine proteinases. 5. The inhibition of trypsin, plasmin and thrombin caused by aliphatic amidino compounds having ether structure as well as esters of the 3- and 4-amidinophenoxyfacetic acid].[丝氨酸蛋白酶的合成抑制剂。5. 具有醚结构的脂肪族脒基化合物以及3-和4-脒基苯氧基乙酸酯对胰蛋白酶、纤溶酶和凝血酶的抑制作用]
Pharmazie. 1975 Jun;30(6):386-9.
9
[Synthetic inhibitors of serine proteinases. 20. The inhibitory effect of benzo condensed lactam derivatives of benzamidine on trypsin, plasmin and thrombin].[丝氨酸蛋白酶的合成抑制剂。20. 脒基苯并稠合内酰胺衍生物对胰蛋白酶、纤溶酶和凝血酶的抑制作用]
Pharmazie. 1979;34(3):194-5.
10
[Synthetic inhibitors of serine proteinases. 10. The inhibition of trypsin, plasmin and thrombin by 4-amidinophenylaralkanone].
Pharmazie. 1976;31(12):886-8.

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1
Multivalent Benzamidine Molecules for Plasmin Inhibition: Effect of Valency and Linker Length.多价苯甲脒分子对纤溶酶的抑制作用:价态和连接子长度的影响。
ChemMedChem. 2022 Nov 18;17(22):e202200364. doi: 10.1002/cmdc.202200364. Epub 2022 Oct 10.