Boura A L, Boyle L, Sinnathuray T A, Walters W A
Br J Pharmacol. 1979 Mar;65(3):360-2. doi: 10.1111/j.1476-5381.1979.tb07838.x.
Flow rate was measured through the vein of the human isolated umbilical cord perfused at constant pressure (40 mmHg) at 37.5 degrees C and 20 degrees C. At the latter temperature the flow was decreased by 50.9% when compared with a mean of 201 ml/min at 37.5 degrees C indicating venospasm. Indomethacin (10 microgram/g) effected a highly significant reduction in the venous spasm caused by lowering the temperature. After indomethacin pretreatment, changing the cord temperature from 37.5 degrees C to 20 degrees C caused a mean decrease in flow of only 3.1%. When the effluent from the vein was passed over rat isolated stomach fundus and colonic strips, cooling of the cord was accompanied by contractions of the isolated tissues characteristic of prostaglandins. These results suggest that prostaglandins are involved in temperature-induced closure of the human umbilical vein after birth.
在37.5摄氏度和20摄氏度下，通过在恒定压力（40 mmHg）下灌注的人体离体脐带静脉测量流速。在20摄氏度时，与37.5摄氏度时平均201毫升/分钟相比，血流量减少了50.9%，表明存在静脉痉挛。吲哚美辛（10微克/克）可显著减轻因降温引起的静脉痉挛。吲哚美辛预处理后，将脐带温度从37.5摄氏度降至20摄氏度，血流量平均仅减少3.1%。当静脉流出物通过大鼠离体胃底和结肠条时，脐带冷却伴随着前列腺素特征性的离体组织收缩。这些结果表明，前列腺素参与出生后温度诱导的人脐静脉关闭。
