普萘洛尔对缺氧心肌中溶酶体的稳定作用。
Stabilization of lysosomes in anoxic myocardium by propranolol.
作者信息
Welman E
出版信息
Br J Pharmacol. 1979 Mar;65(3):479-82. doi: 10.1111/j.1476-5381.1979.tb07854.x.
Abstract
- Isolated hearts of guinea-pigs were perfused aerobically and anoxically for 60 min. (+/-)-Propranolol was added to the perfusion medium in concentrations ranging from 10 ng to 10 microgram/ml. 2. Lysosome stability was assessed by measurements of latent acid hydrolase activity in homogenates of left ventricular tissue. 3. In the absence of propranolol, the integrity of the myocardial lysosomes was considerably reduced after 60 min anoxia. Lysosome stability was enhanced by the presence of (+/-)-propranolol. The optimal concentration was found to be 0.1 microgram/ml. This concentration of the (+)-isomer alone was less effective. 4. It was concluded that beta-adrenoceptor blockade was the major mechanism by which lysosome disruption was prevented but that some direct membrane effect of propranolol may also be involved.
摘要
- 对豚鼠离体心脏进行有氧和无氧灌注60分钟。将（±）-普萘洛尔以10纳克至10微克/毫升的浓度添加到灌注培养基中。2. 通过测量左心室组织匀浆中潜在酸性水解酶活性来评估溶酶体稳定性。3. 在没有普萘洛尔的情况下，缺氧60分钟后心肌溶酶体的完整性显著降低。（±）-普萘洛尔的存在增强了溶酶体稳定性。发现最佳浓度为0.1微克/毫升。单独使用该浓度的（+）-异构体效果较差。4. 得出的结论是，β-肾上腺素能受体阻断是防止溶酶体破坏的主要机制，但普萘洛尔的一些直接膜效应可能也参与其中。
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