普萘洛尔治疗实验性心肌缺血所诱导的超微结构和生化改变。
Ultrastructural and biochemical alterations induced by propranolol treatment in experimental myocardial ischaemia.
作者信息
Laky D, Constantinescu S, Filipescu G, Constantinescu N M, Ratea E, Hălălău F
出版信息
Morphol Embryol (Bucur). 1981 Jul-Sep;27(3):249-53.
The effect of propranolol within the first ten days after a transient experimental myocardial ischaemia was investigated. As compared to the untreated control lot, the ultrastructural and biochemical lesions appeared to be much reduced and within reversible limits. Worthy of note was the slight affection of mitochondria revealed by the level of mitochondrial enzymes, the presence of lysosomal and phagolysosomal structures and capillaries of normal aspect, and the absence of cytolysis. The favourable effect of this beta-blocking drug might be attributed to its protective action on the cellular and capillary membrane systems.
研究了普萘洛尔在短暂性实验性心肌缺血后前十天内的作用。与未治疗的对照组相比，超微结构和生化损伤似乎大大减轻，且在可逆范围内。值得注意的是，线粒体酶水平显示线粒体仅有轻微损伤，存在溶酶体和吞噬溶酶体结构以及外观正常的毛细血管，且无细胞溶解现象。这种β受体阻滞剂的有利作用可能归因于其对细胞和毛细血管膜系统的保护作用。
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