大鼠糖尿病中的肾移植
Renal transplantation in diabetes mellitus in rats.
作者信息
Lee C S, Mauer S M, Brown D M, Sutherland D E, Michael A F, Najarian J S
出版信息
J Exp Med. 1974 Apr 1;139(4):793-800. doi: 10.1084/jem.139.4.793.
Abstract
Immunoglobulins and complement are deposited in the glomerular mesangium of rats with progressive glomerulosclerosis secondary to chemically induced diabetes mellitus. Isotransplantation of a kidney from a rat diabetic for 6 mo into a normal recipient results within 2 mo in the disappearance of IgG, IgM, and beta(1)C from the mesangium and arrest or reversal of the light microscopic glomerular lesions. Kidneys isotransplanted from normal donors into diabetic rats developed mesangial matrix thickening and deposition of IgG, IgM) and beta(1)C in the mesangium. No glomerular changes occur upon transplantation of a normal kidney into a normal rat. These findings indicate that diabetic glomerular changes in the rat are reversible and are secondary to the diabetic state rather than to the inducing agent.
摘要
免疫球蛋白和补体沉积于化学诱导的糖尿病继发进行性肾小球硬化大鼠的肾小球系膜中。将糖尿病6个月的大鼠肾脏同种移植到正常受体中，2个月内系膜中的IgG、IgM和β(1)C消失，光镜下肾小球病变停止或逆转。将正常供体的肾脏同种移植到糖尿病大鼠体内，会出现系膜基质增厚以及IgG、IgM和β(1)C在系膜中的沉积。将正常肾脏移植到正常大鼠体内则不会出现肾小球变化。这些发现表明，大鼠的糖尿病性肾小球变化是可逆的，是糖尿病状态而非诱导剂所致的继发性变化。
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本文引用的文献
1
Glomerular lesions in the diabetic rat.糖尿病大鼠的肾小球病变
Arch Pathol (Chic). 1950 Jul;50(1):75-83.
2
The mechanism of the protective action of clamping the renal pedicles of dogs with alloxan diabetes.用四氧嘧啶糖尿病犬夹闭肾蒂的保护作用机制。
J Endocrinol. 1952 Jul;8(3):245-9. doi: 10.1677/joe.0.0080245.
3
The glomerular mesangium. A quantitative analysis.肾小球系膜。定量分析。
Lab Invest. 1968 Dec;19(6):573-9.
4
Cortical sponge kidneys induced in rats by alloxan.
Diabetes. 1970 Jan;19(1):33-44. doi: 10.2337/diab.19.1.33.
5
Renal transplantation in the rat.大鼠肾移植
Br J Surg. 1969 Nov;56(11):818-22. doi: 10.1002/bjs.1800561105.
6
Spontaneous immunoglobulin and complement deposition in glomeruli of diabetic rats.糖尿病大鼠肾小球中自发的免疫球蛋白和补体沉积。
Lab Invest. 1972 Nov;27(5):488-94.
7
Mortality and morbidity in diabetic patients accepted for renal transplantation.
Proc Eur Dial Transplant Assoc. 1972;9:345-58.
8
The glomerular mesangium. I. Kinetic studies of macromolecular uptake in normal and nephrotic rats.肾小球系膜。I. 正常和肾病大鼠中大分子摄取的动力学研究。
J Clin Invest. 1972 May;51(5):1092-101. doi: 10.1172/JCI106901.
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