Aronstam A, Rainsford S G, Painter M J
Br Med J. 1979 Feb 17;1(6161):469-70. doi: 10.1136/bmj.1.6161.469.
Eighty-two boys with severe haemophilia A who spent some time at Lord Mayor Treloar College during 1973-7 were studied. All episodes of bleeding that occurred during term time were recorded, along with the number of transfusions. The bleeding frequency among these boys, most of them aged 10-17 years, increased steadily from 8,31 episodes/100 days in 1973 to 12,63 episodes/100 days in 1977. At the same time there was a steady fall in bleeding frequency with age. Altogether 24% of bleeding episodes were into the elbow joint, 22% into the knee, and 15% into the ankle. As the boys grew older the proportion of bleeding episodes in the legs declined and that in the arms increased. The overall results reflect the fact that special schools now see only the severest cases of haemophilia. The pattern of bleeding during adolescence suggests that concepts of management of arm bleeding need modifying.
对1973年至1977年期间在特雷洛尔市长勋爵学院待过一段时间的82名重度甲型血友病男孩进行了研究。记录了学期期间发生的所有出血事件以及输血次数。这些男孩大多年龄在10至17岁之间，其出血频率从1973年的每100天8.31次稳步增加到1977年的每100天12.63次。与此同时，出血频率随年龄稳步下降。总共有24%的出血事件发生在肘关节，22%发生在膝关节，15%发生在踝关节。随着男孩年龄的增长，腿部出血事件的比例下降，而手臂出血事件的比例增加。总体结果反映了一个事实，即现在特殊学校里见到的只是最严重的血友病病例。青春期的出血模式表明，手臂出血的管理观念需要改变。
