链脲佐菌素诱导的糖尿病大鼠小肠中结合型胆汁盐主动转运增加。
Increase of active transport of conjugated bile salts in streptozotocin-diabetic rat small intestine.
作者信息
Caspary W F
出版信息
Gut. 1973 Dec;14(12):949-55. doi: 10.1136/gut.14.12.949.
Abstract
Active transport of conjugated bile salts, Na-tauro- and Na-glycocholate and D-galactose, was examined in the small intestine of streptozotocin-diabetic rats by an in-vitro technique. Tissue uptake and mucosal to serosal transport of conjugated bile salts and D-galactose was enhanced in diabetic rat ileum. The minimal transport capacity for conjugated bile salts in the jejunum did not differ between diabetic and control intestine. D-galactose transport and transport of 3-0-methyl-glucose were, however, enhanced in diabetic jejunum as well. Kinetic analysis of the initial uptake rates for conjugated bile salts revealed that the maximal transport capacity (Vmax) was enhanced in diabetic ileum. In accordance with earlier results on the effect of experimental diabetes mellitus on digestive-absorptive functions it is suggested that experimental diabetes mellitus increases the transport capacity of active, Na(+)-dependent intestinal transport processes in general.
摘要
采用体外技术，对链脲佐菌素诱导的糖尿病大鼠小肠中结合型胆盐、牛磺胆酸钠和甘氨胆酸钠以及D-半乳糖的主动转运进行了研究。糖尿病大鼠回肠中结合型胆盐和D-半乳糖的组织摄取及黏膜到浆膜的转运增强。糖尿病和对照小肠空肠中结合型胆盐的最小转运能力无差异。然而，糖尿病空肠中D-半乳糖转运和3-O-甲基葡萄糖转运也增强。结合型胆盐初始摄取率的动力学分析表明，糖尿病回肠中的最大转运能力（Vmax）增强。根据早期关于实验性糖尿病对消化吸收功能影响的研究结果，提示实验性糖尿病总体上增加了主动的、依赖Na⁺的肠道转运过程的转运能力。
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