戊巴比妥对兔视网膜γ-氨基酸自发外流的影响。

Effect of pentobarbitone on the spontaneous efflux of gamma-amino acids from rabbit retina.

作者信息

Bauer B

出版信息

Brain Res. 1979 Mar 16;163(2):307-17. doi: 10.1016/0006-8993(79)90358-5.

Abstract

The effect of pentobarbitone on the spontaneous release of radioactivity from rabbit retinas preloaded with [3H]GABA, [3H]DABA, [3H]beta-alanine and [3H]glycine was studied. In high concentration of pentobarbitone (10(-3)M) the rate of spontaneous efflux of neuronal [3H]GABA, [3H]DABA and [3H]beta-alanine was reduced but not that of [3H]glycine. Glial release of [3H]GABA was much less influenced. At lower concentrations (10(-4)-10(-5)M) there was an initial increase in the release of [3H]GABA, [3H]DABA and [oH]beta-alanine followed by a decrease, indicating several components in the release system for the amino acids.

摘要

研究了戊巴比妥对预先加载[3H]γ-氨基丁酸（[3H]GABA）、[3H]二氨基丁酸（[3H]DABA）、[3H]β-丙氨酸和[3H]甘氨酸的兔视网膜放射性自发释放的影响。在高浓度戊巴比妥（10⁻³M）时，神经元[3H]GABA、[3H]DABA和[3H]β-丙氨酸的自发流出率降低，但[3H]甘氨酸的流出率未降低。[3H]GABA的胶质细胞释放受影响较小。在较低浓度（10⁻⁴ - 10⁻⁵M）时，[3H]GABA、[3H]DABA和[3H]β-丙氨酸的释放最初增加，随后减少，表明氨基酸释放系统中有几个成分。