Kubo T
Can J Physiol Pharmacol. 1979 Jan;57(1):59-64. doi: 10.1139/y79-009.
Pressor reactivity to a variety of pressor agents after partial ganglionic blockade induced with hexamethonium was investigated in intact, in spinalized, and in chemically sympathectomized, spontaneously hypertensive rats (SHR). Responses of unanaesthetized 6-month-old SHR to noradrenaline, phenylephrine, and angiotensin after hexamethonium administration (32 mg/kg) markedly exceeded those of unanaesthetized, age-matched normotensive Wistar-Kyoto rats (WKR). Responses of anaesthetized SHR to noradrenaline after hexamethonium administration (16 mg/kg) were also increased at the hypertensive stages but not at the prehypertensive stages, when compared with those of anaesthetized normotensive Wistar rats of respective ages. In spinalized and chemically sympathectomized preparations after hexamethonium administration (16 mg/kg), noradrenaline produced equal increases in blood pressure in 6-month-old SHR and WKR. It is suggested that the functional sympathetic nervous system is important for the hyperreactivity of intact SHR.
在完整、脊髓横断以及化学性交感神经切除的自发性高血压大鼠（SHR）中，研究了用六甲铵诱导部分神经节阻断后对多种升压剂的升压反应性。给予六甲铵（32毫克/千克）后，未麻醉的6月龄SHR对去甲肾上腺素、苯肾上腺素和血管紧张素的反应明显超过未麻醉的、年龄匹配的正常血压Wistar-Kyoto大鼠（WKR）。与相应年龄的麻醉正常血压Wistar大鼠相比，给予六甲铵（16毫克/千克）后，麻醉的SHR在高血压阶段对去甲肾上腺素的反应也增加，但在高血压前期阶段没有增加。在给予六甲铵（16毫克/千克）后，脊髓横断和化学性交感神经切除的制备中，去甲肾上腺素使6月龄SHR和WKR的血压升高幅度相同。提示功能性交感神经系统对完整SHR的高反应性很重要。
