Bernier G, Phaneuf J B, Filion R
Can J Comp Med. 1974 Jul;38(3):280-5.
This study represents an analysis of the principal clinical factors and pathological lesions of 150 cases of necrotic enteritis encountered during 1968 and 1969 in Quebec. Following multiple investigations no common factor was observed which might have explained the pathogenesis of the condition which was observed during every month of the year, especially from May to November. Birds two to four weeks of age were the most susceptible. The main lesion was a fibrino-necrotic enteritis always localized in the small intestine, either in its entire length or just a segment and characterized by the disappearance of the surface epithelium and necrosis of the villi. The lumen was filled with desquamated epithelial cells and bacteria. Foci of coagulation necrosis were observed in the liver and foci of nephrosis in the kidneys. A Gram+ bacillus, strictly anaerobic, was always isolated from the viscera.
本研究对1968年和1969年在魁北克遇到的150例坏死性肠炎的主要临床因素和病理病变进行了分析。经过多次调查,未观察到可能解释该病发病机制的共同因素,该病在一年中的每个月都有发生,尤其是从5月到11月。2至4周龄的禽类最易感染。主要病变是纤维蛋白坏死性肠炎,总是局限于小肠,可累及整个长度或仅一段,其特征是表面上皮消失和绒毛坏死。肠腔内充满脱落的上皮细胞和细菌。在肝脏中观察到凝固性坏死灶,在肾脏中观察到肾病灶。从内脏中总是分离出一种革兰氏阳性杆菌,严格厌氧。