Kakizoe T, Wang T T, Eng V W, Furrer R, Dion P, Bruce W R
Cancer Res. 1979 Mar;39(3):829-32.
Volatile N-nitrosamines were detected in the urine of male volunteers with gas-liquid and high-pressure liquid chromatography interfaced to the thermal energy analyzer. Of 50 samples from normal males, 10 contained nitrosodimethylamine (0.02 to 0.10 micrograms/liter), 6 contained nitrosodiethylamine (0.02 to 3.10), 9 contained nitrosomorpholine (0.006 to 0.67), and none contained nitrosodibutylamine. Of 4 samples from bladder cancer patients, 2 contained nitrosodibutylamine (0.35 and 0.66). Cigarette smoking did not appear to be related to the pattern or amount of urinary volatile N-nitrosamines. The possibility that the N-nitrosamines arise from the diet or from endogenous production is considered.
采用气液色谱法和与热能分析仪联用的高压液相色谱法，在男性志愿者的尿液中检测到了挥发性N-亚硝胺。在50份正常男性的样本中，10份含有亚硝基二甲胺（0.02至0.10微克/升），6份含有亚硝基二乙胺（0.02至3.10），9份含有亚硝基吗啉（0.006至0.67），且均未检测到亚硝基二丁胺。在4份膀胱癌患者的样本中，2份含有亚硝基二丁胺（0.35和0.66）。吸烟似乎与尿液中挥发性N-亚硝胺的模式或含量无关。研究考虑了N-亚硝胺来源于饮食或内源性产生的可能性。
