Haas R J, Rohruber W, Netzel B, Lau E
Cancer Treat Rep. 1979 Mar;63(3):377-83.
The effect of orally administered CCNU on proliferating and cytokinetically "resting" bone marrow cells was studied in rats. The resting bone marrow cells were selectively labeled with 3H-thymidine by the "complete 3H-thymidine labeling method." The results show a reduction in the number of absolute bone marrow cells to about 40% of the original value in 3 days. Regeneration was completed only after 22 days. No difference was found in the destructive or the regenerative pattern of CFU-C, myelopoietic, erythropoietic, lymphatic, or megakaryocytic cells. Resting and proliferating cells of the bone marrow were equally affected by CCNU.
研究了口服环己亚硝脲（CCNU）对大鼠骨髓增殖细胞和细胞动力学上“静止”的骨髓细胞的影响。采用“完全3H-胸腺嘧啶核苷标记法”用3H-胸腺嘧啶核苷对静止骨髓细胞进行选择性标记。结果显示，3天内绝对骨髓细胞数量减少至原来的约40%。仅在22天后再生才完成。在集落形成单位-粒细胞（CFU-C）、髓系、红系、淋巴系或巨核系细胞的破坏或再生模式上未发现差异。骨髓的静止细胞和增殖细胞受CCNU的影响相同。
