33型肺炎克雷伯菌荚膜多糖的结构研究

Structural studies of the capsular polysaccharide of Klebsiella type 33.

作者信息

Lindberg B, Lindh F, Lönngren J, Nimmich W

出版信息

Carbohydr Res. 1979 Apr;70(1):135-44. doi: 10.1016/s0008-6215(00)83277-2.

DOI:10.1016/s0008-6215(00)83277-2

Abstract

The structure of the capsular polysaccharide from Klebsiella type 33 has been investigated. Methylation analysis, various specific degradations, graded hydrolysis with acid, and n.m.r. spectroscopy were the principal methods used. It is concluded that the polysaccharide is composed of pentasaccharide repeating-units having the following structure. (formula, see manual). The D-galactopyranosyl group, with pyruvic acid linked as a ketal to O-3 AND O-4, was degraded on treatment of the fully methylated polysaccharide with strong base. It is proposed that methyl pyruvate is eliminated, in an E2 type of reaction.

摘要

对33型肺炎克雷伯菌的荚膜多糖结构进行了研究。甲基化分析、各种特异性降解、酸分级水解和核磁共振光谱是主要使用的方法。得出的结论是，该多糖由具有以下结构的五糖重复单元组成。（分子式见手册）。在强碱处理完全甲基化的多糖时，与丙酮酸以缩酮形式连接到O-3和O-4的D-吡喃半乳糖基被降解。有人提出，丙酮酸甲酯是通过E2型反应被消除的。

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