伴刀豆球蛋白A对小鼠腹腔巨噬细胞的影响。I. 对胞吞活性的刺激及对吞噬溶酶体形成的抑制
Effects of concanavalin A on mouse peritoneal macrophages. I. Stimulation of endocytic activity and inhibition of phago-lysosome formation.
作者信息
Edelson P J, Cohn Z A
出版信息
J Exp Med. 1974 Nov 1;140(5):1364-86. doi: 10.1084/jem.140.5.1364.
Abstract
Concanavalin A (Con A) binds to saccharide residues on the mouse peritoneal macrophage plasma membrane and stimulates extensive pinocytic interiorization of the membrane. The overall pinocytic rate is increased 3.5-4.5 times by the addition of Con A, and the surface marker enzyme adenosine triphosphatase can be identified histochemically in association with the cytoplasmic vesicles generated after exposure of the cells to Con A. Once formed, these pinocytic vesicles may persist for several days and fail to show morphologic evidence of fusion with primary or preformed secondary lysosomes. There is no apparent effect on the capacity of the macrophage to ingest either latex particles or IgG-coated SRBC administered either simultaneously with or subsequent to the Con A.
摘要
伴刀豆球蛋白A（Con A）与小鼠腹膜巨噬细胞质膜上的糖类残基结合，并刺激膜的广泛胞饮内化。添加Con A后，总体胞饮速率提高3.5 - 4.5倍，并且表面标记酶三磷酸腺苷酶可通过组织化学方法鉴定，其与细胞暴露于Con A后产生的细胞质小泡相关。一旦形成，这些胞饮小泡可能会持续数天，并且未显示出与初级或预先形成的次级溶酶体融合的形态学证据。Con A与乳胶颗粒或IgG包被的SRBC同时或在Con A之后给药，对巨噬细胞摄取这些物质的能力没有明显影响。
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1
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J Bacteriol. 1936 Aug;32(2):227-37. doi: 10.1128/jb.32.2.227-237.1936.
2
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J Biol Chem. 1951 Nov;193(1):265-75.
3
PROTEIN-CARBOHYDRATE INTERACTION. II. INHIBITION STUDIES ON THE INTERACTION OF CONCANAVALIN A WITH POLYSACCHARIDES.蛋白质-碳水化合物相互作用。II. 伴刀豆球蛋白A与多糖相互作用的抑制研究。
Biochemistry. 1965 May;4:876-83. doi: 10.1021/bi00881a013.
4
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J Histochem Cytochem. 1966 Apr;14(4):291-302. doi: 10.1177/14.4.291.
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