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由活流感病毒在非人类灵长类动物中诱发的中枢神经系统病变。

Lesions of the central nervous system induced in nonhuman primates by live influenza viruses.

作者信息

Lussier G, Boudreault A, Pavilanis V, DiFranco E

出版信息

Can J Comp Med. 1974 Oct;38(4):398-405.

PMID:4279758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1319841/
Abstract

Intracerebral and intraspinal inoculations of non-neuropathic and neuropathic strains of influenza virus into rhesus, patas and cercopithecus monkeys resulted in an acute focal ependymitis, choroiditis and meningitis followed by focal ependymal denuding without parenchymal involvement. Aqueductal stenosis and moderate hydrocephalus developed in two animals as sequelae of ependymal cell loss.

摘要

将非神经病变型和神经病变型流感病毒株接种到恒河猴、粗尾猴和猕猴的脑内和脊髓内，会引发急性局灶性室管膜炎、脉络膜炎和脑膜炎，随后出现局灶性室管膜剥脱，而实质未受累。两只动物出现导水管狭窄和中度脑积水，这是室管膜细胞丢失的后遗症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/7db72717a88d/compmed00048-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/125d23beb1da/compmed00048-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/2cb73554faaa/compmed00048-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/b0b5f013af7f/compmed00048-0061-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/67b608e22ea8/compmed00048-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/1b2c51000b3d/compmed00048-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/b394b7e0835c/compmed00048-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/56a6cb7915d7/compmed00048-0063-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/7db72717a88d/compmed00048-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/125d23beb1da/compmed00048-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/2cb73554faaa/compmed00048-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/b0b5f013af7f/compmed00048-0061-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/67b608e22ea8/compmed00048-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/1b2c51000b3d/compmed00048-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/b394b7e0835c/compmed00048-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/56a6cb7915d7/compmed00048-0063-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f2/1319841/7db72717a88d/compmed00048-0064-a.jpg

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The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.1893年至2014年非人灵长类动物在季节性、大流行性和禽流感研究中的应用
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Mouse hydrocephalus and encephalitis following intracerebral infection with Newcastle disease vaccine viruses.新城疫疫苗病毒脑内感染后小鼠出现脑积水和脑炎。
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本文引用的文献

1
Intracerebral inoculation of mice; fate of the inoculum.小鼠脑内接种；接种物的归宿
Nature. 1950 Nov 25;166(4230):910-1. doi: 10.1038/166910b0.
2
Intracerebral injections and the growth of viruses in the mouse brain.脑内注射与病毒在小鼠脑内的生长
Br J Exp Pathol. 1960 Feb;41(1):52-9.
3
ENCEPHALOPATHY FOLLOWING INFLUENZA IMMUNIZATION.流感疫苗接种后出现的脑病
J Pediatr. 1964 Nov;65:745-8. doi: 10.1016/s0022-3476(64)80160-8.
4
Neurotropic and non-neurotropic influenza-A infection of mouse brain studied with fluorescent antibody.用荧光抗体研究甲型流感病毒对小鼠脑的嗜神经和非嗜神经感染。
J Pathol Bacteriol. 1959 Oct;78:423-33. doi: 10.1002/path.1700780209.
5
An analysis of the toxicity for mice of influenza virus. I. Intracerebral toxicity.流感病毒对小鼠的毒性分析。I. 脑内毒性。
Br J Exp Pathol. 1960 Dec;41(6):586-92.
6
Encephalopathy due to influenza vaccine.流感疫苗所致脑病
AMA Arch Intern Med. 1956 Jun;97(6):803-5. doi: 10.1001/archinte.1956.00250240155017.
7
Relapsing encephalomyelitis following the use of influenza vaccine.使用流感疫苗后发生的复发性脑脊髓炎。
Arch Neurol. 1972 Aug;27(2):182-3. doi: 10.1001/archneur.1972.00490140086012.
8
Influenza virus encephalitis in squirrel monkeys receiving immunosuppressive therapy.接受免疫抑制治疗的松鼠猴中的流感病毒脑炎
J Immunol. 1971 Apr;106(4):1119-21.
9
Influenzal encephalitis in mice. A histopathological and electron microscopical study.小鼠流感性脑炎。一项组织病理学和电子显微镜研究。
Arch Gesamte Virusforsch. 1971;34(2):157-67. doi: 10.1007/BF01241717.
10
The choroid plexus: a historical review.脉络丛：历史回顾
Brain Res. 1970 Mar 3;18(2):197-218. doi: 10.1016/0006-8993(70)90324-0.